EMBO workshop - Eukaryotic RNA turnover and viral biology

VAŇÁČOVÁ, Štěpánka and Šárka FAJTLOVÁ. EMBO workshop - Eukaryotic RNA turnover and viral biology. 2023.

Basic information

Original name

EMBO workshop - Eukaryotic RNA turnover and viral biology

Authors

VAŇÁČOVÁ, Štěpánka (203 Czech Republic, guarantor, belonging to the institution) and Šárka FAJTLOVÁ (203 Czech Republic, belonging to the institution)

Edition

2023

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Other information

Language

English

Type of outcome

Uspořádání konference

Field of Study

10606 Microbiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14740/23:00133579

Organization unit

Central European Institute of Technology

Keywords in English

viruses; structure; RNA interactions and modifications; translation and replication; virus infections; antiviral therapies; virus host interactions

Tags

rivok

Tags

International impact

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Abstract

V originále

Viruses are major human pathogens that cause a wide range of infectious diseases, representing a constantly recurring challenge to the health of individuals and the functioning of human society. Only a profound understanding of viral biology will provide the basis for developing and improving antiviral therapies. While RNA turnover has long been studied in the context of cellular gene regulation and quality control mechanisms, the interplay between RNA turnover and viral life cycles is only now emerging as a key component of virus-host interactions. For example, Herpes viruses, Poxvirus, Influenza virus and SARS-Coronavirus encode ribonucleases that cleave host mRNA and thereby support virus reproduction. Flaviviruses such as Dengue virus, West Nile virus and Hepatitis C virus encode a non-coding RNA that blocks Xrn1, a major cellular exoribonuclease, as a means to escape from an antiviral activity. The endonuclease RNase L is another component of the mammalian antiviral defense system, highlighting the importance of ribonucleases in the encounter of viruses with their host cells. This EMBO Workshop will bring together molecular biologists working on basic mechanisms controlling RNA turnover with virologists exploring RNA turnover in the context of virus-host interactions, and propel the scientific exchange in this emerging area of research.