| VONDRASEK, David, Daniel HADRABA, Jan PŘIBYL, Adam ECKHARDT, Martin OSTADAL, Frantisek LOPOT, Karel JELEN, Martina DOUBKOVA, Jarmila KNITLOVA, Tomas NOVOTNY and Jiri JANACEK. Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue. Microscopy and Microanalysis. Saarbrücken: Cambridge University Press, 2023, vol. 29, No 1, p. 265-272. ISSN 1431-9276. Available from: https://dx.doi.org/10.1093/micmic/ozac012. |
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@article{2376978,
author = {Vondrasek, David and Hadraba, Daniel and Přibyl, Jan and Eckhardt, Adam and Ostadal, Martin and Lopot, Frantisek and Jelen, Karel and Doubkova, Martina and Knitlova, Jarmila and Novotny, Tomas and Janacek, Jiri},
article_location = {Saarbrücken},
article_number = {1},
doi = {http://dx.doi.org/10.1093/micmic/ozac012},
keywords = {atomic force microscopy; label-free imaging; mechanical properties; multi-modal analysis; orthopedic surgery; relapsed clubfoot; talipes equinovarus congenitus},
language = {eng},
issn = {1431-9276},
journal = {Microscopy and Microanalysis},
title = {Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue},
url = {https://academic.oup.com/mam/article/29/1/265/6948117?login=true},
volume = {29},
year = {2023}
}
TY - JOUR
ID - 2376978
AU - Vondrasek, David - Hadraba, Daniel - Přibyl, Jan - Eckhardt, Adam - Ostadal, Martin - Lopot, Frantisek - Jelen, Karel - Doubkova, Martina - Knitlova, Jarmila - Novotny, Tomas - Janacek, Jiri
PY - 2023
TI - Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue
JF - Microscopy and Microanalysis
VL - 29
IS - 1
SP - 265-272
EP - 265-272
PB - Cambridge University Press
SN - 14319276
KW - atomic force microscopy
KW - label-free imaging
KW - mechanical properties
KW - multi-modal analysis
KW - orthopedic surgery
KW - relapsed clubfoot
KW - talipes equinovarus congenitus
UR - https://academic.oup.com/mam/article/29/1/265/6948117?login=true
N2 - Talipes equinovarus congenitus (clubfoot) is frequently defined as a stiff, contracted deformity, but few studies have described the tissue from the point of view of the extracellular matrix, and none have quantified its mechanical properties. Several researchers have observed that clubfoot exhibits signs of fibrosis in the medial side of the deformity that are absent in the lateral side. Our study aims to quantify the differences between the medial and lateral side tissue obtained from relapsed clubfoot during surgery in terms of the morphological and mechanical properties of the tissue. Combining methods of optical and atomic force microscopy, our study revealed that the medial side has a higher Young's modulus, contains more collagen and less adipose tissue and that the collagen fibers propagate at a higher frequency of the crimp pattern after surgical dissection of the tissue. Our study offers a multi-correlative approach that thoroughly investigates the relapsed clubfoot tissue.
ER -
VONDRASEK, David, Daniel HADRABA, Jan PŘIBYL, Adam ECKHARDT, Martin OSTADAL, Frantisek LOPOT, Karel JELEN, Martina DOUBKOVA, Jarmila KNITLOVA, Tomas NOVOTNY and Jiri JANACEK. Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue. \textit{Microscopy and Microanalysis}. Saarbrücken: Cambridge University Press, 2023, vol.~29, No~1, p.~265-272. ISSN~1431-9276. Available from: https://dx.doi.org/10.1093/micmic/ozac012.
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