VONDRASEK, David, Daniel HADRABA, Jan PŘIBYL, Adam ECKHARDT, Martin OSTADAL, Frantisek LOPOT, Karel JELEN, Martina DOUBKOVA, Jarmila KNITLOVA, Tomas NOVOTNY and Jiri JANACEK. Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue. Microscopy and Microanalysis. Saarbrücken: Cambridge University Press, 2023, vol. 29, No 1, p. 265-272. ISSN 1431-9276. Available from: https://dx.doi.org/10.1093/micmic/ozac012. |
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@article{2376978, author = {Vondrasek, David and Hadraba, Daniel and Přibyl, Jan and Eckhardt, Adam and Ostadal, Martin and Lopot, Frantisek and Jelen, Karel and Doubkova, Martina and Knitlova, Jarmila and Novotny, Tomas and Janacek, Jiri}, article_location = {Saarbrücken}, article_number = {1}, doi = {http://dx.doi.org/10.1093/micmic/ozac012}, keywords = {atomic force microscopy; label-free imaging; mechanical properties; multi-modal analysis; orthopedic surgery; relapsed clubfoot; talipes equinovarus congenitus}, language = {eng}, issn = {1431-9276}, journal = {Microscopy and Microanalysis}, title = {Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue}, url = {https://academic.oup.com/mam/article/29/1/265/6948117?login=true}, volume = {29}, year = {2023} }
TY - JOUR ID - 2376978 AU - Vondrasek, David - Hadraba, Daniel - Přibyl, Jan - Eckhardt, Adam - Ostadal, Martin - Lopot, Frantisek - Jelen, Karel - Doubkova, Martina - Knitlova, Jarmila - Novotny, Tomas - Janacek, Jiri PY - 2023 TI - Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue JF - Microscopy and Microanalysis VL - 29 IS - 1 SP - 265-272 EP - 265-272 PB - Cambridge University Press SN - 14319276 KW - atomic force microscopy KW - label-free imaging KW - mechanical properties KW - multi-modal analysis KW - orthopedic surgery KW - relapsed clubfoot KW - talipes equinovarus congenitus UR - https://academic.oup.com/mam/article/29/1/265/6948117?login=true N2 - Talipes equinovarus congenitus (clubfoot) is frequently defined as a stiff, contracted deformity, but few studies have described the tissue from the point of view of the extracellular matrix, and none have quantified its mechanical properties. Several researchers have observed that clubfoot exhibits signs of fibrosis in the medial side of the deformity that are absent in the lateral side. Our study aims to quantify the differences between the medial and lateral side tissue obtained from relapsed clubfoot during surgery in terms of the morphological and mechanical properties of the tissue. Combining methods of optical and atomic force microscopy, our study revealed that the medial side has a higher Young's modulus, contains more collagen and less adipose tissue and that the collagen fibers propagate at a higher frequency of the crimp pattern after surgical dissection of the tissue. Our study offers a multi-correlative approach that thoroughly investigates the relapsed clubfoot tissue. ER -
VONDRASEK, David, Daniel HADRABA, Jan PŘIBYL, Adam ECKHARDT, Martin OSTADAL, Frantisek LOPOT, Karel JELEN, Martina DOUBKOVA, Jarmila KNITLOVA, Tomas NOVOTNY and Jiri JANACEK. Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue. \textit{Microscopy and Microanalysis}. Saarbrücken: Cambridge University Press, 2023, vol.~29, No~1, p.~265-272. ISSN~1431-9276. Available from: https://dx.doi.org/10.1093/micmic/ozac012.
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