Emergency medicine pharmacotherapy compromises accuracy of
plasma creatinine determination by enzyme-based methods:
real-world clinical evidence and implications for clinical
practice

J 2024

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

DEMLOVÁ, Regina, Šárka KOZÁKOVÁ, Michal ŘIHÁČEK, Dana BUČKOVÁ, Kateřina HORSKÁ et. al.

Basic information

Original name

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

Authors

DEMLOVÁ, Regina (203 Czech Republic, belonging to the institution), Šárka KOZÁKOVÁ (203 Czech Republic, belonging to the institution), Michal ŘIHÁČEK (203 Czech Republic, belonging to the institution), Dana BUČKOVÁ (203 Czech Republic, belonging to the institution), Kateřina HORSKÁ (203 Czech Republic, belonging to the institution), Ondřej WIEWIORKA (203 Czech Republic, belonging to the institution), Luboš BOUČEK (203 Czech Republic), Iveta SELINGEROVÁ (203 Czech Republic, belonging to the institution), Martina PODBORSKÁ (203 Czech Republic, belonging to the institution), Alena KORBEROVÁ (203 Czech Republic), Alena MIKUŠKOVÁ (203 Czech Republic, belonging to the institution), Jiří ŠTARHA (203 Czech Republic, belonging to the institution), Miroslava BEŇOVSKÁ (203 Czech Republic, belonging to the institution), Martin RADINA (203 Czech Republic), Michal RICHTER (203 Czech Republic), Lenka ZDRAŽILOVÁ DUBSKÁ (203 Czech Republic, belonging to the institution) and Dalibor VALÍK (203 Czech Republic, belonging to the institution)

Edition

Frontiers in Medicine, Laussane, Frontiers, 2024, 2296-858X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.900 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fmed.2023.1236948

UT WoS

001154759700001

Keywords in English

creatinine; renal functions; eGFR; urgent care medication; cystatin C

Abstract

V originále

Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffe gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population. Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.

Links

CZ.02.1.01/0.0/0.0/16_013/0001826, interní kód MU
(CEP code: EF16_013/0001826)

Name: CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research

101059788, interní kód MU

Name: Central European Advanced Therapy and Immunotherapy Centre

Investor: European Union, Widening participation and strengthening the European Research Area

90249, large research infrastructures

Name: CZECRIN IV

Citovat

DEMLOVÁ, Regina, Šárka KOZÁKOVÁ, Michal ŘIHÁČEK, Dana BUČKOVÁ, Kateřina HORSKÁ, Ondřej WIEWIORKA, Luboš BOUČEK, Iveta SELINGEROVÁ, Martina PODBORSKÁ, Alena KORBEROVÁ, Alena MIKUŠKOVÁ, Jiří ŠTARHA, Miroslava BEŇOVSKÁ, Martin RADINA, Michal RICHTER, Lenka ZDRAŽILOVÁ DUBSKÁ and Dalibor VALÍK. Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice. Frontiers in Medicine. Laussane: Frontiers, 2024, vol. 10, January 2024, p. 1-16. ISSN 2296-858X. Available from: https://dx.doi.org/10.3389/fmed.2023.1236948.

@article{2377086,
   author = {Demlová, Regina and Kozáková, Šárka and Řiháček, Michal and Bučková, Dana and Horská, Kateřina and Wiewiorka, Ondřej and Bouček, Luboš and Selingerová, Iveta and Podborská, Martina and Korberová, Alena and Mikušková, Alena and Štarha, Jiří and Beňovská, Miroslava and Radina, Martin and Richter, Michal and Zdražilová Dubská, Lenka and Valík, Dalibor},
   article_location = {Laussane},
   article_number = {January 2024},
   doi = {http://dx.doi.org/10.3389/fmed.2023.1236948},
   keywords = {creatinine; renal functions; eGFR; urgent care medication; cystatin C},
   language = {eng},
   issn = {2296-858X},
   journal = {Frontiers in Medicine},
   title = {Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice},
   url = {https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1236948/full},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2377086
AU  - Demlová, Regina - Kozáková, Šárka - Řiháček, Michal - Bučková, Dana - Horská, Kateřina - Wiewiorka, Ondřej - Bouček, Luboš - Selingerová, Iveta - Podborská, Martina - Korberová, Alena - Mikušková, Alena - Štarha, Jiří - Beňovská, Miroslava - Radina, Martin - Richter, Michal - Zdražilová Dubská, Lenka - Valík, Dalibor
PY  - 2024
TI  - Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice
JF  - Frontiers in Medicine
VL  - 10
IS  - January 2024
SP  - 1-16
EP  - 1-16
PB  - Frontiers
SN  - 2296858X
KW  - creatinine
KW  - renal functions
KW  - eGFR
KW  - urgent care medication
KW  - cystatin C
UR  - https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1236948/full
N2  - Background: Assessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference. Methods: Real-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffe gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods. Results: In 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population. Conclusion: In a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.
ER  -

DEMLOVÁ, Regina, Šárka KOZÁKOVÁ, Michal ŘIHÁČEK, Dana BUČKOVÁ, Kateřina HORSKÁ, Ondřej WIEWIORKA, Luboš BOUČEK, Iveta SELINGEROVÁ, Martina PODBORSKÁ, Alena KORBEROVÁ, Alena MIKUŠKOVÁ, Jiří ŠTARHA, Miroslava BEŇOVSKÁ, Martin RADINA, Michal RICHTER, Lenka ZDRAŽILOVÁ DUBSKÁ and Dalibor VALÍK. Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice. \textit{Frontiers in Medicine}. Laussane: Frontiers, 2024, vol.~10, January 2024, p.~1-16. ISSN~2296-858X. Available from: https://dx.doi.org/10.3389/fmed.2023.1236948.

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