Effect of treatment with original or biosimilar adalimumab on
SARS-CoV2 vaccination antibody titers

J 2024

Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers

DOKOUPILOVÁ, Eva, David VETCHÝ, Sylvie PAVLOKOVÁ and M. HANUŠTIAKOVÁ

Basic information

Original name

Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers

Authors

DOKOUPILOVÁ, Eva (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution) and M. HANUŠTIAKOVÁ (203 Czech Republic)

Edition

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, NETHERLANDS, SPRINGER, 2024, 2210-7703

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.400 in 2022

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.ijpx.2024.100229

Keywords in English

SARS-CoV-2 Adalimumab Original Biosimilar Autoimmune disease Nonparametric statistics

Abstract

V originále

The technological process of production of biosimilars determines the degree of biosimilarity to the original biological drug. In particular, the focus is on the similarity of immunogenic responses. The primary endpoint of our retrospective study was to find the differences in SARS-CoV-2 antibody amount between patients treated with original adalimumab and biosimilar adalimumab MSB11022 (Idacio) and the differences in the SARS-CoV-2 antibody amount between patients treated with and without biological treatment. We collected the gender, autoimmune disease type, age, and treatment data of the patients in the outpatient clinic MEDICAL PLUS, s.r.o., Uherske Hradiste. These patients suffer from autoimmune rheumatic diseases. All patients received the mRNA vaccine (Pfizer/BioNTech – BNT162b2), with a 21-day (interquartile range, 21–24) gap between the two vaccinations. Patients receiving adalimumab were able to develop cellular immune responses after the second vaccination dose, as well as the individuals without adalimumab. In the period of 6–23 weeks after the second vaccination dose (D63 – D182), the SARS-CoV-2 antibody levels did not change significantly in the patients receiving the original adalimumab, while in the patients receiving biosimilar adalimumab a significant decrease was revealed. A statistically significant difference in the SARS-CoV-2 antibody amount between the patients without biological treatment (median: 504.3 U/mL) and with biological treatment (Original and Biosimilar – median: 47.2 and 28.2 U/mL, respectively) was confirmed on day 182. According to our observation, the effect of the treatment type on the increase/decrease of antibodies over time is dominant, while the impact of other variables (gender, methotrexate treatment, autoimmune disease type, and age) was confirmed as insignificant or minor.

Citovat

DOKOUPILOVÁ, Eva, David VETCHÝ, Sylvie PAVLOKOVÁ and M. HANUŠTIAKOVÁ. Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY. NETHERLANDS: SPRINGER, 2024, Neuveden, No 7, p. 1-10. ISSN 2210-7703. Available from: https://dx.doi.org/10.1016/j.ijpx.2024.100229.

@article{2377120,
   author = {Dokoupilová, Eva and Vetchý, David and Pavloková, Sylvie and Hanuštiaková, M.},
   article_location = {NETHERLANDS},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.ijpx.2024.100229},
   keywords = {SARS-CoV-2 Adalimumab Original Biosimilar Autoimmune disease Nonparametric statistics},
   language = {eng},
   issn = {2210-7703},
   journal = {INTERNATIONAL JOURNAL OF CLINICAL PHARMACY},
   title = {Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers},
   url = {https://www.sciencedirect.com/science/article/pii/S259015672400001X},
   volume = {Neuveden},
   year = {2024}
}

TY  - JOUR
ID  - 2377120
AU  - Dokoupilová, Eva - Vetchý, David - Pavloková, Sylvie - Hanuštiaková, M.
PY  - 2024
TI  - Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers
JF  - INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
VL  - Neuveden
IS  - 7
SP  - 1-10
EP  - 1-10
PB  - SPRINGER
SN  - 22107703
KW  - SARS-CoV-2 Adalimumab Original Biosimilar Autoimmune disease Nonparametric statistics
UR  - https://www.sciencedirect.com/science/article/pii/S259015672400001X
N2  - The technological process of production of biosimilars determines the degree of biosimilarity to the original biological drug. In particular, the focus is on the similarity of immunogenic responses. The primary endpoint of our retrospective study was to find the differences in SARS-CoV-2 antibody amount between patients treated with original adalimumab and biosimilar adalimumab MSB11022 (Idacio) and the differences in the SARS-CoV-2 antibody amount between patients treated with and without biological treatment. We collected the gender, autoimmune disease type, age, and treatment data of the patients in the outpatient clinic MEDICAL PLUS, s.r.o., Uherske Hradiste. These patients suffer from autoimmune rheumatic diseases. All patients received the mRNA vaccine (Pfizer/BioNTech – BNT162b2), with a 21-day (interquartile range, 21–24) gap between the two vaccinations. Patients receiving adalimumab were able to develop cellular immune responses after the second vaccination dose, as well as the individuals without adalimumab. In the period of 6–23 weeks after the second vaccination dose (D63 – D182), the SARS-CoV-2 antibody levels did not change significantly in the patients receiving the original adalimumab, while in the patients receiving biosimilar adalimumab a significant decrease was revealed. A statistically significant difference in the SARS-CoV-2 antibody amount between the patients without biological treatment (median: 504.3 U/mL) and with biological treatment (Original and Biosimilar – median: 47.2 and 28.2 U/mL, respectively) was confirmed on day 182. According to our observation, the effect of the treatment type on the increase/decrease of antibodies over time is dominant, while the impact of other variables (gender, methotrexate treatment, autoimmune disease type, and age) was confirmed as insignificant or minor.
ER  -

DOKOUPILOVÁ, Eva, David VETCHÝ, Sylvie PAVLOKOVÁ and M. HANUŠTIAKOVÁ. Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers. \textit{INTERNATIONAL JOURNAL OF CLINICAL PHARMACY}. NETHERLANDS: SPRINGER, 2024, Neuveden, No~7, p.~1-10. ISSN~2210-7703. Available from: https://dx.doi.org/10.1016/j.ijpx.2024.100229.

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