KRSAKOVA, E., Aleš ČERMÁK and Michal FEDORKO. Comparison of different regimens of short-term antibiotic prophylaxis in transrectal prostate biopsy. The Journal of hospital infection. W B SAUNDERS CO LTD: LONDON, 2024, vol. 145, March 2024, p. 83-87. ISSN 0195-6701. Available from: https://dx.doi.org/10.1016/j.jhin.2023.12.012.
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Basic information
Original name Comparison of different regimens of short-term antibiotic prophylaxis in transrectal prostate biopsy
Authors KRSAKOVA, E. (203 Czech Republic), Aleš ČERMÁK (203 Czech Republic, belonging to the institution) and Michal FEDORKO (203 Czech Republic, belonging to the institution).
Edition The Journal of hospital infection, W B SAUNDERS CO LTD, LONDON, 2024, 0195-6701.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30217 Urology and nephrology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.900 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jhin.2023.12.012
UT WoS 001181110700001
Keywords in English Antibiotic prophylaxis; Complications; Fosfomycin trometamol; Transrectal prostate biopsy
Tags 14110225, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 10/6/2024 10:02.
Abstract
Background Prostate cancer is the most common malignant solid tumour in men aged >70 years and is the second most common cause of death from oncological circumstances. Aim To evaluate the effect of different short-term prophylactic antibiotic regimens in transrectal prostate biopsy (PB) on the incidence of infectious complications. Methods Patients who underwent transrectal ultrasound-guided PB between January 2021 and December 2022 were included in the prospective randomized study. According to the regimen of prophylaxis, patients were randomized into three groups: (1) fosfomycin trometamol 3 g, 3 h before the procedure + ciprofloxacin 500 mg, 2 h before the procedure; (2) fosfomycin trometamol 3 g, 3 h before and 24 h after the procedure; (3) ciprofloxacin 500 mg 12, 2 h before the procedure, and 12 h after the procedure. A rectal swab was performed 1–2 weeks before PB to evaluate the culture findings. Complications were evaluated during follow-up visits within one month after PB. Findings In the monitored period, 605 PBs were performed, and 544 patients met the inclusion criteria (184, 161, and 199 in groups 1, 2, and 3). Infectious complications occurred in 10 cases (1.83%), namely 3, 4, and 3 according to patient groups. There was no statistically significant difference between the individual groups. None of the patients required hospitalization and all were free of symptoms of sepsis. Conclusion Short-term antibiotic prophylaxis in PB using fosfomycin trometamol, ciprofloxacin, or their combination appears to be effective. Fosfomycin trometamol is a suitable alternative to fluoroquinolone antibiotics.
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