J 2024

Comparison of different regimens of short-term antibiotic prophylaxis in transrectal prostate biopsy

KRSAKOVA, E., Aleš ČERMÁK and Michal FEDORKO

Basic information

Original name

Comparison of different regimens of short-term antibiotic prophylaxis in transrectal prostate biopsy

Authors

KRSAKOVA, E. (203 Czech Republic), Aleš ČERMÁK (203 Czech Republic, belonging to the institution) and Michal FEDORKO (203 Czech Republic, belonging to the institution)

Edition

The Journal of hospital infection, W B SAUNDERS CO LTD, LONDON, 2024, 0195-6701

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30217 Urology and nephrology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 6.900 in 2022

Organization unit

Faculty of Medicine

DOI

UT WoS

001181110700001

Keywords in English

Antibiotic prophylaxis; Complications; Fosfomycin trometamol; Transrectal prostate biopsy

Tags

Tags

International impact, Reviewed
Změněno: 10/6/2024 10:02, Mgr. Tereza Miškechová

Abstract

V originále

Background Prostate cancer is the most common malignant solid tumour in men aged >70 years and is the second most common cause of death from oncological circumstances. Aim To evaluate the effect of different short-term prophylactic antibiotic regimens in transrectal prostate biopsy (PB) on the incidence of infectious complications. Methods Patients who underwent transrectal ultrasound-guided PB between January 2021 and December 2022 were included in the prospective randomized study. According to the regimen of prophylaxis, patients were randomized into three groups: (1) fosfomycin trometamol 3 g, 3 h before the procedure + ciprofloxacin 500 mg, 2 h before the procedure; (2) fosfomycin trometamol 3 g, 3 h before and 24 h after the procedure; (3) ciprofloxacin 500 mg 12, 2 h before the procedure, and 12 h after the procedure. A rectal swab was performed 1–2 weeks before PB to evaluate the culture findings. Complications were evaluated during follow-up visits within one month after PB. Findings In the monitored period, 605 PBs were performed, and 544 patients met the inclusion criteria (184, 161, and 199 in groups 1, 2, and 3). Infectious complications occurred in 10 cases (1.83%), namely 3, 4, and 3 according to patient groups. There was no statistically significant difference between the individual groups. None of the patients required hospitalization and all were free of symptoms of sepsis. Conclusion Short-term antibiotic prophylaxis in PB using fosfomycin trometamol, ciprofloxacin, or their combination appears to be effective. Fosfomycin trometamol is a suitable alternative to fluoroquinolone antibiotics.