Detailed Information on Publication Record
2024
Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
YADAV, Anoop Kumar and Hana POLÁŠEK-SEDLÁČKOVÁBasic information
Original name
Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
Authors
YADAV, Anoop Kumar (356 India, belonging to the institution) and Hana POLÁŠEK-SEDLÁČKOVÁ
Edition
Communications Biology, Nature Research, 2024, 2399-3642
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.900 in 2022
Organization unit
Faculty of Science
UT WoS
001159273400002
Keywords in English
EUKARYOTIC DNA-REPLICATION; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; MCM PROTEINS; S-PHASE; NUCLEAR-LOCALIZATION; DORMANT ORIGINS; BIND CHROMATIN; EXCESS MCM2-7; HUMAN MEMBER
Tags
Tags
International impact, Reviewed
Změněno: 23/2/2024 14:11, Mgr. Marie Šípková, DiS.
Abstract
V originále
Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.