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@article{2377568, author = {Yadav, Anoop Kumar and PolášekandSedláčková, Hana}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s42003-024-05855-w}, keywords = {EUKARYOTIC DNA-REPLICATION; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE; MCM PROTEINS; S-PHASE; NUCLEAR-LOCALIZATION; DORMANT ORIGINS; BIND CHROMATIN; EXCESS MCM2-7; HUMAN MEMBER}, language = {eng}, issn = {2399-3642}, journal = {Communications Biology}, title = {Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity}, url = {https://www.nature.com/articles/s42003-024-05855-w}, volume = {7}, year = {2024} }
TY - JOUR ID - 2377568 AU - Yadav, Anoop Kumar - Polášek-Sedláčková, Hana PY - 2024 TI - Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity JF - Communications Biology VL - 7 IS - 1 SP - 1-14 EP - 1-14 PB - Nature Research SN - 23993642 KW - EUKARYOTIC DNA-REPLICATION KW - ORIGIN RECOGNITION COMPLEX KW - CELL-CYCLE KW - MCM PROTEINS KW - S-PHASE KW - NUCLEAR-LOCALIZATION KW - DORMANT ORIGINS KW - BIND CHROMATIN KW - EXCESS MCM2-7 KW - HUMAN MEMBER UR - https://www.nature.com/articles/s42003-024-05855-w N2 - Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies. ER -
YADAV, Anoop Kumar and Hana POLÁŠEK-SEDLÁČKOVÁ. Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity. \textit{Communications Biology}. Nature Research, 2024, vol.~7, No~1, p.~1-14. ISSN~2399-3642. Available from: https://dx.doi.org/10.1038/s42003-024-05855-w.
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