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@article{2377597,
author = {Nečasová, Andrea and Lorenzová, Jana and Řeháková, Kristína and Haruštiaková, Danka and Nečas, Alois},
article_location = {Brno},
article_number = {3},
doi = {http://dx.doi.org/10.2754/avb202392030289},
keywords = {Canine; vascular anomaly; ameroid constrictor; liver; prognostic marker},
language = {eng},
issn = {0001-7213},
journal = {Acta Veterinaria Brno},
title = {Assessment of plasma protein C activity in dogs with portosystemic shunt},
url = {https://actavet.vfu.cz/92/3/0289/},
volume = {92},
year = {2023}
}
TY - JOUR
ID - 2377597
AU - Nečasová, Andrea - Lorenzová, Jana - Řeháková, Kristína - Haruštiaková, Danka - Nečas, Alois
PY - 2023
TI - Assessment of plasma protein C activity in dogs with portosystemic shunt
JF - Acta Veterinaria Brno
VL - 92
IS - 3
SP - 289-302
EP - 289-302
PB - University of Veterinary and Pharmaceutical Sciences
SN - 00017213
KW - Canine
KW - vascular anomaly
KW - ameroid constrictor
KW - liver
KW - prognostic marker
UR - https://actavet.vfu.cz/92/3/0289/
N2 - Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and > 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P < 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog's death (P = 0.334) or the dog's clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.
ER -
NEČASOVÁ, Andrea, Jana LORENZOVÁ, Kristína ŘEHÁKOVÁ, Danka HARUŠTIAKOVÁ and Alois NEČAS. Assessment of plasma protein C activity in dogs with portosystemic shunt. \textit{Acta Veterinaria Brno}. Brno: University of Veterinary and Pharmaceutical Sciences, 2023, vol.~92, No~3, p.~289-302. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb202392030289.
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