J 2023

Assessment of plasma protein C activity in dogs with portosystemic shunt

NEČASOVÁ, Andrea, Jana LORENZOVÁ, Kristína ŘEHÁKOVÁ, Danka HARUŠTIAKOVÁ, Alois NEČAS et. al.

Basic information

Original name

Assessment of plasma protein C activity in dogs with portosystemic shunt

Authors

NEČASOVÁ, Andrea, Jana LORENZOVÁ, Kristína ŘEHÁKOVÁ, Danka HARUŠTIAKOVÁ (703 Slovakia, belonging to the institution) and Alois NEČAS

Edition

Acta Veterinaria Brno, Brno, University of Veterinary and Pharmaceutical Sciences, 2023, 0001-7213

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

40301 Veterinary science

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.600 in 2022

RIV identification code

RIV/00216224:14310/23:00133639

Organization unit

Faculty of Science

DOI

UT WoS

001153359000009

Keywords in English

Canine; vascular anomaly; ameroid constrictor; liver; prognostic marker

Tags

Tags

International impact, Reviewed
Změněno: 1/3/2024 10:35, Mgr. Marie Šípková, DiS.

Abstract

V originále

Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and > 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P < 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog's death (P = 0.334) or the dog's clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.