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@article{2378938,
author = {Gomez Perez, Inmaculada Jennifer and Křížková, Petra and Dolečková, Anna and Cardo, Lucía and Wetzl, Cecilia and Pizúrová, Naděžda and Prato, Maurizio and Medalová, Jiřina and Zajíčková, Lenka},
article_number = {February 2024},
doi = {http://dx.doi.org/10.1016/j.apmt.2024.102072},
keywords = {Bioimaging; Blood-brain barrier; Carbon dots; Memantine; Protein aggregation},
language = {eng},
issn = {2352-9407},
journal = {Applied Materials Today},
title = {Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation},
url = {https://www.sciencedirect.com/science/article/pii/S2352940724000180},
volume = {36},
year = {2024}
}
TY - JOUR
ID - 2378938
AU - Gomez Perez, Inmaculada Jennifer - Křížková, Petra - Dolečková, Anna - Cardo, Lucía - Wetzl, Cecilia - Pizúrová, Naděžda - Prato, Maurizio - Medalová, Jiřina - Zajíčková, Lenka
PY - 2024
TI - Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation
JF - Applied Materials Today
VL - 36
IS - February 2024
SP - 1-9
EP - 1-9
PB - Elsevier Ltd
SN - 23529407
KW - Bioimaging
KW - Blood-brain barrier
KW - Carbon dots
KW - Memantine
KW - Protein aggregation
UR - https://www.sciencedirect.com/science/article/pii/S2352940724000180
N2 - Multifunctional nanoparticles could be the hallmark for the treatment of neurodegenerative diseases. Dissociation of protein aggregates causing neuronal damage and transfer of specific drugs which can downregulate neuronal excitotoxicity by inhibiting glutamatergic N-Methyl-d-Aspartate-receptors (NMDA) and then reducing calcium influx are among the main factors to consider for proper therapy. Here, we present a multiplatform based on nitrogen-doped graphene quantum dots (NGQDs) with such functionalities. The NGQDs were functionalized with Memantine, the clinically used drug, via covalent and non-covalent coupling, and we confirmed that the pharmaceutical activity was not altered. Apart from that, using xCELLigence technology and flow cytometric analysis of ABC transporter function, we uncovered that the ABC transporters of the blood-brain barrier (BBB) do not affect the ability of NGQD to cross BBB. Surprisingly, this study found that NGQDs have an inhibitory effect on NMDA receptors, thus supporting the action of Memantine. Moreover, NGQDs and their derivatives demonstrated the potential to dissociate β-amyloid aggregates while possessing features suitable for bioimaging in various cell lines.
ER -
GOMEZ PEREZ, Inmaculada Jennifer, Petra KŘÍŽKOVÁ, Anna DOLEČKOVÁ, Lucía CARDO, Cecilia WETZL, Naděžda PIZÚROVÁ, Maurizio PRATO, Jiřina MEDALOVÁ and Lenka ZAJÍČKOVÁ. Multifunctional graphene quantum dots: A therapeutic strategy for neurodegenerative diseases by regulating calcium influx, crossing the blood-brain barrier and inhibiting Aβ-protein aggregation. \textit{Applied Materials Today}. Elsevier Ltd, 2024, vol.~36, February 2024, p.~1-9. ISSN~2352-9407. Available from: https://dx.doi.org/10.1016/j.apmt.2024.102072.
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