Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA and Petr HUSA. Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2024, vol. 168, No 2, p. 1-9. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2024.002.

Basic information

Original name

Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression

Authors

HAVLÍČKOVÁ, Kateřina, Svatava SNOPKOVÁ, Miroslav POHANKA, Radek SVAČINKA, David VYDRÁŘ, Petr HUSA, Jiřina ZAVŘELOVÁ, Filip ZLÁMAL, Lenka FABIANOVÁ, Miroslav PENKA and Petr HUSA

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2024, 1213-8118

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.900 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2024.002

UT WoS

001171815400001

Keywords in English

oxidative stress; microparticles;E-selectin; HIV suppression

Tags

14110212, 14110214

Tags

International impact, Reviewed

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Abstract

V originále

Background. Oxidative stress and inflammation are considered predictors of diseases associated with aging. Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Patients and Methods. This study was conducted on 213 subjects with HIV. The control groups consisted of healthy HIV-negative adults. The level of oxidative stress was measured by assessing the production of malondialdehyde levels, which were detected by thiobarbituric acid reactive substance (TBARS) assay. The level of microparticles indicated the presence of inflammation and endothelial activation was measured by E-selectin levels. Significant differences were determined by appropriate statistical tests, depending on the distribution of variables. Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient. Results. TBARS, and microparticle and E-selectin levels were significantly higher in untreated and treated subjects with HIV compared with HIV-negative controls (P<0.001). The levels of the investigated markers were not significantly different between untreated and treated patients and no significant correlation of these markers was found with CD4+ count, CD4+/CD8+ ratio, and the number of HIV-1 RNA copies. Conclusions. Elevated markers of oxidative stress, inflammatory and endothelial activation were independent of the virologic and immunologic status of people with HIV. These results support the hypothesis that residual viremia in cellular reservoirs of various tissues is a key factor related to the premature aging of the immune system and predisposition to the premature development of diseases associated with aging.