Effects of Oral Iron Supplementation on Blood Iron Status in
Athletes: A Systematic Review, Meta-Analysis and
Meta-Regression of Randomized Controlled Trials

J 2024

Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

ŠMID, Anja Neža, Petra GOLJA, Vedran HADŽIĆ, Ensar ABAZOVIĆ, Kristina DROLE et. al.

Basic information

Original name

Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Authors

ŠMID, Anja Neža, Petra GOLJA, Vedran HADŽIĆ, Ensar ABAZOVIĆ, Kristina DROLE and Armin PARAVLIĆ

Edition

SPORTS MEDICINE, NEW ZEALAND, ADIS INT LTD, 2024, 0112-1642

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30306 Sport and fitness sciences

Country of publisher

New Zealand

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.800 in 2022

Organization unit

Faculty of Sports Studies

DOI

http://dx.doi.org/10.1007/s40279-024-01992-8

Změněno: 27/2/2024 13:55, Ing. Petra Svobodníková

Abstract

V originále

Background Iron defciency in athletes is initially treated with a nutritional intervention. If negative iron balance persists, oral iron supplementation (OIS) can be used. Despite the recent proposal for a refnement of treatment strategies for irondefcient athletes, there is no general consensus regarding the actual efciency, dosage, or optimal regimen of OIS. Objective The aim of this meta-analysis was to evaluate to what extent OIS afects blood iron parameters and physical performance in healthy adult athletes. Methods PubMed, Web of Science, PEDro, CINAHL, SPORTDiscus, and Cochrane were searched from inception to 2 November 2022. Articles were eligible if they satisfed the following criteria: recruited subjects were healthy, adult and physically active individuals, who used exclusively OIS, irrespective of sex and sports discipline. Exclusion criteria: simultaneous supplementation with iron and any other micronutrient(s), intravenous iron supplementation or recent exposure to altitude acclimatisation. The methodological quality of included studies was assessed with the PEDro scale, the completeness of intervention reporting with the TIDieR scale, while the GRADE scale was used for quality of evidence synthesis. The present study was prospectively registered in PROSPERO online registry (ID: CRD42022330230). Results From 638 articles identifed through the search, 13 studies (n=449) were included in the quantitative synthesis. When compared to the control group, the results demonstrated that OIS increases serum ferritin (standardized mean difference (SMD)=1.27, 95% CI 0.44–2.10, p=0.006), whereas blood haemoglobin (SMD=1.31, 95% CI − 0.29 to 2.93, p=0.099), serum transferrin receptor concentration (SMD=− 0.74, 95% CI − 1.89 to 0.41, p=0.133), and transferrin saturation (SMD=0.69, 95% CI − 0.84 to 2.22, p=0.330) remained unaltered. Following OIS, a trend of small positive efect on VO2max (SMD=0.49, 95% CI − 0.09 to 1.07, p=0.086) was observed in young healthy athletes. The quality of evidence for all outcomes ranged from moderate to low. Conclusions Increase in serum ferritin concentration after OIS was evident in subjects with initial pre-supplementation serum ferritin concentration≤12 µg/l, while only minimal, if any efect, was observed in subjects with higher pre-supplementation serum ferritin concentration. The doses of OIS, that induced a benefcial efect on hematological parameters difered from 16 to 100 mg of elementary iron daily, over the period between 6 and 8 weeks. Shorter supplementation protocols have been shown to be inefective.

Citovat

ŠMID, Anja Neža, Petra GOLJA, Vedran HADŽIĆ, Ensar ABAZOVIĆ, Kristina DROLE and Armin PARAVLIĆ. Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials. SPORTS MEDICINE. NEW ZEALAND: ADIS INT LTD, 2024, vol. 54, No 1, p. 1-17. ISSN 0112-1642. Available from: https://dx.doi.org/10.1007/s40279-024-01992-8.

@article{2379125,
   author = {Šmid, Anja Neža and Golja, Petra and Hadžić, Vedran and Abazović, Ensar and Drole, Kristina and Paravlić, Armin},
   article_location = {NEW ZEALAND},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s40279-024-01992-8},
   language = {eng},
   issn = {0112-1642},
   journal = {SPORTS MEDICINE},
   title = {Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials},
   url = {https://link.springer.com/article/10.1007/s40279-024-01992-8?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240226&utm_content=10.1007/s40279-024-01992-8#Abs1},
   volume = {54},
   year = {2024}
}

TY  - JOUR
ID  - 2379125
AU  - Šmid, Anja Neža - Golja, Petra - Hadžić, Vedran - Abazović, Ensar - Drole, Kristina - Paravlić, Armin
PY  - 2024
TI  - Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials
JF  - SPORTS MEDICINE
VL  - 54
IS  - 1
SP  - 1-17
EP  - 1-17
PB  - ADIS INT LTD
SN  - 01121642
UR  - https://link.springer.com/article/10.1007/s40279-024-01992-8?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240226&utm_content=10.1007/s40279-024-01992-8#Abs1
N2  - Background Iron defciency in athletes is initially treated with a nutritional intervention. If negative iron balance persists, oral iron supplementation (OIS) can be used. Despite the recent proposal for a refnement of treatment strategies for irondefcient athletes, there is no general consensus regarding the actual efciency, dosage, or optimal regimen of OIS. Objective The aim of this meta-analysis was to evaluate to what extent OIS afects blood iron parameters and physical performance in healthy adult athletes. Methods PubMed, Web of Science, PEDro, CINAHL, SPORTDiscus, and Cochrane were searched from inception to 2 November 2022. Articles were eligible if they satisfed the following criteria: recruited subjects were healthy, adult and physically active individuals, who used exclusively OIS, irrespective of sex and sports discipline. Exclusion criteria: simultaneous supplementation with iron and any other micronutrient(s), intravenous iron supplementation or recent exposure to altitude acclimatisation. The methodological quality of included studies was assessed with the PEDro scale, the completeness of intervention reporting with the TIDieR scale, while the GRADE scale was used for quality of evidence synthesis. The present study was prospectively registered in PROSPERO online registry (ID: CRD42022330230). Results From 638 articles identifed through the search, 13 studies (n=449) were included in the quantitative synthesis. When compared to the control group, the results demonstrated that OIS increases serum ferritin (standardized mean difference (SMD)=1.27, 95% CI 0.44–2.10, p=0.006), whereas blood haemoglobin (SMD=1.31, 95% CI − 0.29 to 2.93, p=0.099), serum transferrin receptor concentration (SMD=− 0.74, 95% CI − 1.89 to 0.41, p=0.133), and transferrin saturation (SMD=0.69, 95% CI − 0.84 to 2.22, p=0.330) remained unaltered. Following OIS, a trend of small positive efect on VO2max (SMD=0.49, 95% CI − 0.09 to 1.07, p=0.086) was observed in young healthy athletes. The quality of evidence for all outcomes ranged from moderate to low. Conclusions Increase in serum ferritin concentration after OIS was evident in subjects with initial pre-supplementation serum ferritin concentration≤12 µg/l, while only minimal, if any efect, was observed in subjects with higher pre-supplementation serum ferritin concentration. The doses of OIS, that induced a benefcial efect on hematological parameters difered from 16 to 100 mg of elementary iron daily, over the period between 6 and 8 weeks. Shorter supplementation protocols have been shown to be inefective.
ER  -

ŠMID, Anja Neža, Petra GOLJA, Vedran HADŽI$\backslash$'C, Ensar ABAZOVI$\backslash$'C, Kristina DROLE and Armin PARAVLI$\backslash$'C. Effects of Oral Iron Supplementation on Blood Iron Status in Athletes: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials. \textit{SPORTS MEDICINE}. NEW ZEALAND: ADIS INT LTD, 2024, vol.~54, No~1, p.~1-17. ISSN~0112-1642. Available from: https://dx.doi.org/10.1007/s40279-024-01992-8.

Detailed Information on Publication Record