CAHOVA, Jana, Jana BLAHOVA, Lucie PLHALOVA, Petr MARSALEK, Veronika DOUBKOVA, Martin HOSTOVSKY, Lenka DIVIŠOVÁ, Jan MARES, Caterina FAGGIO and Zdenka SVOBODOVA. Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish<i> (Danio</i><i> rerio)?</i>. Veterinarni Medicina. Prague: CZECH ACAD AGRIC SCI, 2023, vol. 68, No 5, p. 218-224. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/40/2023-VETMED.
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Basic information
Original name Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish<i> (Danio</i><i> rerio)?</i>
Authors CAHOVA, Jana (203 Czech Republic), Jana BLAHOVA (203 Czech Republic), Lucie PLHALOVA (203 Czech Republic), Petr MARSALEK (203 Czech Republic), Veronika DOUBKOVA (203 Czech Republic), Martin HOSTOVSKY (203 Czech Republic), Lenka DIVIŠOVÁ (203 Czech Republic, belonging to the institution), Jan MARES (203 Czech Republic), Caterina FAGGIO and Zdenka SVOBODOVA (203 Czech Republic).
Edition Veterinarni Medicina, Prague, CZECH ACAD AGRIC SCI, 2023, 0375-8427.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 40300 4.3 Veterinary science
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.700 in 2022
RIV identification code RIV/00216224:14110/23:00133660
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.17221/40/2023-VETMED
UT WoS 001001809800005
Keywords in English aquatic contamination; endocrine disruptor; oxidative stress; personal care products; vitellogenin
Tags rivok
Tags Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 27/2/2024 14:31.
Abstract
Polycyclic musk compounds are commonly used in personal care products to replace expensive natural fragrances. Due to their huge consumption, they have become a part of the aquatic environment. In the present a two-month exposure effect of tonalide on juvenile zebrafish (Danio rerio) was investigated. We deter-mined the vitellogenin concentration to define the potential endocrine-disrupting effect of tonalide and also ana-selected indices to evaluate the induction of oxidative stress. The environmentally relevant concentration tonalide (i.e., 500 ng/l) caused a significant decrease in the catalase activity (P < 0.05) and a significant increase 0.05) in the lipid peroxidation. An increasing lipid peroxidation was also recorded for the highest concentra-group tested (i.e., 50 000 ng/l). On the other hand, no significant changes were recorded in vitellogenin in all exposed groups. Thus, based on these results, we have not demonstrated the endocrine-disrupting activity tonalide in zebrafish. The results of the oxidative stress indices showed a significant impairment of the anti-oxidant defence after the two-month tonalide exposure, which could indicate part of the adaptive response tonalide toxicity.
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