Examining the association between posttraumatic stress disorder
and disruptions in cortical networks identified using
data-driven methods

J 2024

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL et. al.

Basic information

Original name

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Authors

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution), Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY (guarantor) and Aristeidis SOTIRAS

Edition

Neuropsychopharmacology, London, SPRINGERNATURE, 2024, 0893-133X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.600 in 2022

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41386-023-01763-5

UT WoS

001123265200001

Keywords in English

posttraumatic stress disorder; disruptions; cortical networks

Abstract

V originále

Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.

Links

NV18-04-00559, research and development project

Name: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministry of Health of the CR, Neurobiological and psychological markers of reaction to extreme stress and its impact on offspring - three generation study of holocaust survivors and their offspring

Citovat

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA, Ivan REKTOR, Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY and Aristeidis SOTIRAS. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology. London: SPRINGERNATURE, 2024, vol. 49, No 3, p. 609-619. ISSN 0893-133X. Available from: https://dx.doi.org/10.1038/s41386-023-01763-5.

@article{2379563,
   author = {Yang, Jin and Huggins, Ashley A and Sun, Delin and Baird, C Lexi and Haswell, Courtney C and Frijling, Jessie L and Olff, Miranda and Mirjam, van Zuiden and Koch, Saskia B J and Nawijn, Laura and Veltman, Dick J and SuarezandJimenez, Benjamin and Zhu, Xi and Neria, Yuval and Hudson, Anna R and Mueller, Sven C and Baker, Justin T and Lebois, Lauren A M and Kaufman, Milissa L and Qi, Rongfeng and Lu, Guang Ming and Říha, Pavel and Rektor, Ivan and Dennis, Emily L and Ching, Christopher R K and Thomopoulos, Sophia I and Salminen, Lauren E and Jahanshad, Neda and Thompson, Paul M and Stein, Dan J and Koopowitz, Sheri M and Ipser, Jonathan C and Seedat, Soraya and Stefan, du Plessis and van den Heuvel, Leigh L and Wang, Li and Zhu, Ye and Li, Gen and Sierk, Anika and Manthey, Antje and Walter, Henrik and Daniels, Judith K and Schmahl, Christian and Herzog, Julia I and Liberzon, Israel and King, Anthony and Angstadt, Mike and Davenport, Nicholas D and Sponheim, Scott R and Disner, Seth G and Straube, Thomas and Hofmann, David and Grupe, Daniel W and Nitschke, Jack B and Davidson, Richard J and Larson, Christine L and deRoonandCassini, Terri A and Blackford, Jennifer U and Olatunji, Bunmi O and Gordon, Evan M and May, Geoffrey and Nelson, Steven M and Abdallah, Chadi G and Levy, Ifat and HarpazandRotem, Ilan and Krystal, John H and Morey, Rajendra A and Sotiras, Aristeidis},
   article_location = {London},
   article_number = {3},
   doi = {http://dx.doi.org/10.1038/s41386-023-01763-5},
   keywords = {posttraumatic stress disorder; disruptions; cortical networks},
   language = {eng},
   issn = {0893-133X},
   journal = {Neuropsychopharmacology},
   title = {Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods},
   url = {https://www.nature.com/articles/s41386-023-01763-5},
   volume = {49},
   year = {2024}
}

TY  - JOUR
ID  - 2379563
AU  - Yang, Jin - Huggins, Ashley A - Sun, Delin - Baird, C Lexi - Haswell, Courtney C - Frijling, Jessie L - Olff, Miranda - Mirjam, van Zuiden - Koch, Saskia B J - Nawijn, Laura - Veltman, Dick J - Suarez-Jimenez, Benjamin - Zhu, Xi - Neria, Yuval - Hudson, Anna R - Mueller, Sven C - Baker, Justin T - Lebois, Lauren A M - Kaufman, Milissa L - Qi, Rongfeng - Lu, Guang Ming - Říha, Pavel - Rektor, Ivan - Dennis, Emily L - Ching, Christopher R K - Thomopoulos, Sophia I - Salminen, Lauren E - Jahanshad, Neda - Thompson, Paul M - Stein, Dan J - Koopowitz, Sheri M - Ipser, Jonathan C - Seedat, Soraya - Stefan, du Plessis - van den Heuvel, Leigh L - Wang, Li - Zhu, Ye - Li, Gen - Sierk, Anika - Manthey, Antje - Walter, Henrik - Daniels, Judith K - Schmahl, Christian - Herzog, Julia I - Liberzon, Israel - King, Anthony - Angstadt, Mike - Davenport, Nicholas D - Sponheim, Scott R - Disner, Seth G - Straube, Thomas - Hofmann, David - Grupe, Daniel W - Nitschke, Jack B - Davidson, Richard J - Larson, Christine L - deRoon-Cassini, Terri A - Blackford, Jennifer U - Olatunji, Bunmi O - Gordon, Evan M - May, Geoffrey - Nelson, Steven M - Abdallah, Chadi G - Levy, Ifat - Harpaz-Rotem, Ilan - Krystal, John H - Morey, Rajendra A - Sotiras, Aristeidis
PY  - 2024
TI  - Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
JF  - Neuropsychopharmacology
VL  - 49
IS  - 3
SP  - 609-619
EP  - 609-619
PB  - SPRINGERNATURE
SN  - 0893133X
KW  - posttraumatic stress disorder
KW  - disruptions
KW  - cortical networks
UR  - https://www.nature.com/articles/s41386-023-01763-5
N2  - Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.
ER  -

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA, Ivan REKTOR, Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY and Aristeidis SOTIRAS. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. \textit{Neuropsychopharmacology}. London: SPRINGERNATURE, 2024, vol.~49, No~3, p.~609-619. ISSN~0893-133X. Available from: https://dx.doi.org/10.1038/s41386-023-01763-5.

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