| MARKEZANA, Aurelia, Mor PALDOR, Haixing LIAO, Muneeb AHMED, Elina ZORDE-KHVALEVSKY, Nir ROZENBLUM, Matthias STECHELE, Lukas SALVERMOSER, Flinn LAVILLE, Salome GOLDMANN, Nofar ROSENBERG, Tomáš ANDRAŠINA, Jens RICKE, Eithan GALUN and Shraga Nahum GOLDBERG. Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation. Nature Scientific Reports. BERLIN: NATURE PORTFOLIO, 2023, vol. 13, No 1, p. 1-16. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-023-42819-2. |
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@article{2379575,
author = {Markezana, Aurelia and Paldor, Mor and Liao, Haixing and Ahmed, Muneeb and ZordeandKhvalevsky, Elina and Rozenblum, Nir and Stechele, Matthias and Salvermoser, Lukas and Laville, Flinn and Goldmann, Salome and Rosenberg, Nofar and Andrašina, Tomáš and Ricke, Jens and Galun, Eithan and Goldberg, Shraga Nahum},
article_location = {BERLIN},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-023-42819-2},
keywords = {fibroblast growth factors; hepatic tumorigenesis post radiofrequency ablation},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation},
url = {https://www.nature.com/articles/s41598-023-42819-2},
volume = {13},
year = {2023}
}
TY - JOUR
ID - 2379575
AU - Markezana, Aurelia - Paldor, Mor - Liao, Haixing - Ahmed, Muneeb - Zorde-Khvalevsky, Elina - Rozenblum, Nir - Stechele, Matthias - Salvermoser, Lukas - Laville, Flinn - Goldmann, Salome - Rosenberg, Nofar - Andrašina, Tomáš - Ricke, Jens - Galun, Eithan - Goldberg, Shraga Nahum
PY - 2023
TI - Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation
JF - Nature Scientific Reports
VL - 13
IS - 1
SP - 1-16
EP - 1-16
PB - NATURE PORTFOLIO
SN - 20452322
KW - fibroblast growth factors
KW - hepatic tumorigenesis post radiofrequency ablation
UR - https://www.nature.com/articles/s41598-023-42819-2
N2 - Image-guided radiofrequency ablation (RFA) is used to treat focal tumors in the liver and other organs. Despite potential advantages over surgery, hepatic RFA can promote local and distant tumor growth by activating pro-tumorigenic growth factor and cytokines. Thus, strategies to identify and suppress pro-oncogenic effects of RFA are urgently required to further improve the therapeutic effect. Here, the proliferative effect of plasma of Hepatocellular carcinoma or colorectal carcinoma patients 90 min post-RFA was tested on HCC cell lines, demonstrating significant cellular proliferation compared to baseline plasma. Multiplex ELISA screening demonstrated increased plasma pro-tumorigenic growth factors and cytokines including the FGF protein family which uniquely and selectively activated HepG2. Primary mouse and immortalized human hepatocytes were then subjected to moderate hyperthermia in-vitro, mimicking thermal stress induced during ablation in the peri-ablational normal tissue. Resultant culture medium induced proliferation of multiple cancer cell lines. Subsequent non-biased protein array revealed that these hepatocytes subjected to moderate hyperthermia also excrete a similar wide spectrum of growth factors. Recombinant FGF-2 activated multiple cell lines. FGFR inhibitor significantly reduced liver tumor load post-RFA in MDR2-KO inflammation-induced HCC mouse model. Thus, Liver RFA can induce tumorigenesis via the FGF signaling pathway, and its inhibition suppresses HCC development.
ER -
MARKEZANA, Aurelia, Mor PALDOR, Haixing LIAO, Muneeb AHMED, Elina ZORDE-KHVALEVSKY, Nir ROZENBLUM, Matthias STECHELE, Lukas SALVERMOSER, Flinn LAVILLE, Salome GOLDMANN, Nofar ROSENBERG, Tomáš ANDRAŠINA, Jens RICKE, Eithan GALUN and Shraga Nahum GOLDBERG. Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation. \textit{Nature Scientific Reports}. BERLIN: NATURE PORTFOLIO, 2023, vol.~13, No~1, p.~1-16. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-023-42819-2.
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