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@article{2381702,
author = {Strebel, Sven and Baust, Katja and Grabow, Desiree and Byrne, Julianne and Langer, Thorsten and ZehnhoffandDinnesen, Antoinette Am and Kuonen, Rahel and Weiss, Annette and Kepák, Tomáš and Kruseova, Jarmila and Berger, Claire and Calaminus, Gabriele and Sommer, Grit and Kuehni, Claudia E},
article_location = {New York},
doi = {http://dx.doi.org/10.1007/s11764-023-01456-4},
keywords = {Childhood cancer; Survivorship; Quality of life; Hearing loss; Tinnitus},
language = {eng},
issn = {1932-2259},
journal = {JOURNAL OF CANCER SURVIVORSHIP},
title = {Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study},
url = {https://link.springer.com/article/10.1007/s11764-023-01456-4},
year = {2024}
}
TY - JOUR
ID - 2381702
AU - Strebel, Sven - Baust, Katja - Grabow, Desiree - Byrne, Julianne - Langer, Thorsten - Zehnhoff-Dinnesen, Antoinette Am - Kuonen, Rahel - Weiss, Annette - Kepák, Tomáš - Kruseova, Jarmila - Berger, Claire - Calaminus, Gabriele - Sommer, Grit - Kuehni, Claudia E
PY - 2024
TI - Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study
JF - JOURNAL OF CANCER SURVIVORSHIP
PB - SPRINGER
SN - 19322259
KW - Childhood cancer
KW - Survivorship
KW - Quality of life
KW - Hearing loss
KW - Tinnitus
UR - https://link.springer.com/article/10.1007/s11764-023-01456-4
N2 - PurposeAuditory complications are potential side effects from childhood cancer treatment. Yet, limited evidence exists about the impact of auditory complications-particularly tinnitus-on health-related quality of life (HRQoL) among childhood cancer survivors (CCS). We determined the prevalence of hearing loss and tinnitus in the European PanCareLIFE cohort of CCS and examined its effect on HRQoL.MethodsWe included CCS from four European countries who were diagnosed at age & LE; 18 years; survived & GE; 5 years; and aged 25-44 years at study. We assessed HRQoL (Short Form 36), hearing loss, and tinnitus using questionnaires. We used multivariable linear regression to examine associations between these two auditory complications and HRQoL adjusting for socio-demographic and clinical factors.ResultsOur study population consisted of 6,318 CCS (53% female; median age at cancer diagnosis 9 years interquartile range [IQR] 5-13 years) with median age at survey of 31 years (IQR 28-35 years). Prevalence was 7.5% (476/6,318; confidence interval [CI]: 6.9-8.2) for hearing loss and 7.6% (127/1,668; CI: 6.4-9.0) for tinnitus. CCS with hearing loss had impaired physical (coefficient [coef.] -4.3, CI: -7.0 to -1.6) and mental (coef. -3.2, CI: -5.5 to -0.8) HRQoL when compared with CCS with normal hearing. Tinnitus was associated with impaired physical (coef. -8.2, CI: -11.8 to -4.7) and mental (coef. -5.9, CI: -8.8 to -3.1) HRQoL.ConclusionWe observed reduced HRQoL among CCS with hearing loss and tinnitus. Our findings indicate timely treatment of hearing loss and tinnitus may contribute to quality of life of survivors.Implications for cancer survivorsCCS who experience auditory complications should be counseled about possible therapeutic and supportive measures during follow-up care.
ER -
STREBEL, Sven, Katja BAUST, Desiree GRABOW, Julianne BYRNE, Thorsten LANGER, Antoinette Am ZEHNHOFF-DINNESEN, Rahel KUONEN, Annette WEISS, Tomáš KEPÁK, Jarmila KRUSEOVA, Claire BERGER, Gabriele CALAMINUS, Grit SOMMER and Claudia E KUEHNI. Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study. \textit{JOURNAL OF CANCER SURVIVORSHIP}. New York: SPRINGER, 2024, 12 pp. ISSN~1932-2259. Available from: https://dx.doi.org/10.1007/s11764-023-01456-4.
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