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@article{2381762, author = {Mukherjee, Soumajit and Bytesnikova, Zuzana and Martin, Sophie and Svec, Pavel and Ridoskova, Andrea and Pekarkova, Jana and Seguin, Cendrine and Weickert, JeanandLuc and Messaddeq, Nadia and Mely, Yves and Richtera, Lukas and Anton, Halina and Adam, Vojtech}, article_location = {HOBOKEN}, article_number = {6}, doi = {http://dx.doi.org/10.1002/admi.202201996}, keywords = {antiviral activity; graphene oxide; human immunodeficiency virus-1; immune response; lipid peroxidation; silver nanoparticles}, language = {eng}, issn = {2196-7350}, journal = {Advanced Materials Interfaces}, title = {Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection}, url = {https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996}, volume = {10}, year = {2023} }
TY - JOUR ID - 2381762 AU - Mukherjee, Soumajit - Bytesnikova, Zuzana - Martin, Sophie - Svec, Pavel - Ridoskova, Andrea - Pekarkova, Jana - Seguin, Cendrine - Weickert, Jean-Luc - Messaddeq, Nadia - Mely, Yves - Richtera, Lukas - Anton, Halina - Adam, Vojtech PY - 2023 TI - Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection JF - Advanced Materials Interfaces VL - 10 IS - 6 SP - 1-15 EP - 1-15 PB - Wiley SN - 21967350 KW - antiviral activity KW - graphene oxide KW - human immunodeficiency virus-1 KW - immune response KW - lipid peroxidation KW - silver nanoparticles UR - https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996 N2 - Graphene-based 2D nanomaterials exhibit unique physicochemical, electric, and optical properties that facilitate applications in a wide range of fields including material science, electronics, and biotechnology. Recent studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) exhibit antimicrobial effects on bacteria and viruses. While the bactericidal activity of graphene-based nanomaterials is related to mechanical and oxidative damage to bacterial membranes, their antiviral activity has been less explored. Currently available experimental data are limited and suggest mechanical disruption of viral particles prior to infection. In this study, the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) are evidenced against human immunodeficiency virus-1 pseudovirus used as an enveloped virus model. By combining biochemical and original single virus imaging approaches, it is shown that rGO-Ag induces peroxidation of pseudoviral lipid membrane and that consequent alteration of membrane properties leads to a reduction in cell entry. In addition, rGO-Ag is found to be efficiently internalized in the host cell leading to the elevated expression of pro-inflammatory cytokines. Altogether, the presented results shed new light on the mechanisms of rGO-Ag antiviral properties and confirm the high potential of graphene derivatives as an antimicrobial material for biomedical applications. ER -
MUKHERJEE, Soumajit, Zuzana BYTESNIKOVA, Sophie MARTIN, Pavel SVEC, Andrea RIDOSKOVA, Jana PEKARKOVA, Cendrine SEGUIN, Jean-Luc WEICKERT, Nadia MESSADDEQ, Yves MELY, Lukas RICHTERA, Halina ANTON a Vojtech ADAM. Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection. \textit{Advanced Materials Interfaces}. HOBOKEN: Wiley, 2023, roč.~10, č.~6, s.~1-15. ISSN~2196-7350. Dostupné z: https://dx.doi.org/10.1002/admi.202201996.
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