Silver Nanoparticle-Decorated Reduced Graphene Oxide
Nanomaterials Exert Membrane Stress and Induce Immune Response
to Inhibit the Early Phase of HIV-1 Infection

J 2023

Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

MUKHERJEE, Soumajit, Zuzana BYTESNIKOVA, Sophie MARTIN, Pavel SVEC, Andrea RIDOSKOVA et. al.

Basic information

Original name

Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

Authors

Edition

Advanced Materials Interfaces, HOBOKEN, Wiley, 2023, 2196-7350

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20500 2.5 Materials engineering

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400 in 2022

RIV identification code

RIV/00216224:90242/23:00133733

DOI

http://dx.doi.org/10.1002/admi.202201996

UT WoS

000895508500001

Keywords in English

antiviral activity; graphene oxide; human immunodeficiency virus-1; immune response; lipid peroxidation; silver nanoparticles

Abstract

V originále

Graphene-based 2D nanomaterials exhibit unique physicochemical, electric, and optical properties that facilitate applications in a wide range of fields including material science, electronics, and biotechnology. Recent studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) exhibit antimicrobial effects on bacteria and viruses. While the bactericidal activity of graphene-based nanomaterials is related to mechanical and oxidative damage to bacterial membranes, their antiviral activity has been less explored. Currently available experimental data are limited and suggest mechanical disruption of viral particles prior to infection. In this study, the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) are evidenced against human immunodeficiency virus-1 pseudovirus used as an enveloped virus model. By combining biochemical and original single virus imaging approaches, it is shown that rGO-Ag induces peroxidation of pseudoviral lipid membrane and that consequent alteration of membrane properties leads to a reduction in cell entry. In addition, rGO-Ag is found to be efficiently internalized in the host cell leading to the elevated expression of pro-inflammatory cytokines. Altogether, the presented results shed new light on the mechanisms of rGO-Ag antiviral properties and confirm the high potential of graphene derivatives as an antimicrobial material for biomedical applications.

Links

90242, large research infrastructures

Name: CIISB III

Citovat

MUKHERJEE, Soumajit, Zuzana BYTESNIKOVA, Sophie MARTIN, Pavel SVEC, Andrea RIDOSKOVA, Jana PEKARKOVA, Cendrine SEGUIN, Jean-Luc WEICKERT, Nadia MESSADDEQ, Yves MELY, Lukas RICHTERA, Halina ANTON and Vojtech ADAM. Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection. Advanced Materials Interfaces. HOBOKEN: Wiley, 2023, vol. 10, No 6, p. 1-15. ISSN 2196-7350. Available from: https://dx.doi.org/10.1002/admi.202201996.

@article{2381762,
   author = {Mukherjee, Soumajit and Bytesnikova, Zuzana and Martin, Sophie and Svec, Pavel and Ridoskova, Andrea and Pekarkova, Jana and Seguin, Cendrine and Weickert, JeanandLuc and Messaddeq, Nadia and Mely, Yves and Richtera, Lukas and Anton, Halina and Adam, Vojtech},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/admi.202201996},
   keywords = {antiviral activity; graphene oxide; human immunodeficiency virus-1; immune response; lipid peroxidation; silver nanoparticles},
   language = {eng},
   issn = {2196-7350},
   journal = {Advanced Materials Interfaces},
   title = {Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996},
   volume = {10},
   year = {2023}
}

TY  - JOUR
ID  - 2381762
AU  - Mukherjee, Soumajit - Bytesnikova, Zuzana - Martin, Sophie - Svec, Pavel - Ridoskova, Andrea - Pekarkova, Jana - Seguin, Cendrine - Weickert, Jean-Luc - Messaddeq, Nadia - Mely, Yves - Richtera, Lukas - Anton, Halina - Adam, Vojtech
PY  - 2023
TI  - Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection
JF  - Advanced Materials Interfaces
VL  - 10
IS  - 6
SP  - 1-15
EP  - 1-15
PB  - Wiley
SN  - 21967350
KW  - antiviral activity
KW  - graphene oxide
KW  - human immunodeficiency virus-1
KW  - immune response
KW  - lipid peroxidation
KW  - silver nanoparticles
UR  - https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996
N2  - Graphene-based 2D nanomaterials exhibit unique physicochemical, electric, and optical properties that facilitate applications in a wide range of fields including material science, electronics, and biotechnology. Recent studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) exhibit antimicrobial effects on bacteria and viruses. While the bactericidal activity of graphene-based nanomaterials is related to mechanical and oxidative damage to bacterial membranes, their antiviral activity has been less explored. Currently available experimental data are limited and suggest mechanical disruption of viral particles prior to infection. In this study, the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) are evidenced against human immunodeficiency virus-1 pseudovirus used as an enveloped virus model. By combining biochemical and original single virus imaging approaches, it is shown that rGO-Ag induces peroxidation of pseudoviral lipid membrane and that consequent alteration of membrane properties leads to a reduction in cell entry. In addition, rGO-Ag is found to be efficiently internalized in the host cell leading to the elevated expression of pro-inflammatory cytokines. Altogether, the presented results shed new light on the mechanisms of rGO-Ag antiviral properties and confirm the high potential of graphene derivatives as an antimicrobial material for biomedical applications.
ER  -

MUKHERJEE, Soumajit, Zuzana BYTESNIKOVA, Sophie MARTIN, Pavel SVEC, Andrea RIDOSKOVA, Jana PEKARKOVA, Cendrine SEGUIN, Jean-Luc WEICKERT, Nadia MESSADDEQ, Yves MELY, Lukas RICHTERA, Halina ANTON and Vojtech ADAM. Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection. \textit{Advanced Materials Interfaces}. HOBOKEN: Wiley, 2023, vol.~10, No~6, p.~1-15. ISSN~2196-7350. Available from: https://dx.doi.org/10.1002/admi.202201996.

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