Cryo-EM structures of Trypanosoma brucei gambiense ISG65
with human complement C3 and C3b and their roles in alternative
pathway restriction

J 2023

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH et. al.

Basic information

Original name

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

Authors

Edition

Nature Communications, Berlin, Nature, 2023, 2041-1723

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 16.600 in 2022

RIV identification code

RIV/00216224:90242/23:00133765

DOI

http://dx.doi.org/10.1038/s41467-023-37988-7

UT WoS

000989625000023

Keywords in English

VARIANT SURFACE GLYCOPROTEIN; ANTIGENIC DETERMINANTS; SPONTANEOUS HYDROLYSIS; HUMAN-SERUM; PROTEIN; resistance

Abstract

V originále

African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement interaction.

Links

90242, large research infrastructures

Name: CIISB III

Citovat

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER and Sebastian ZOLL. Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nature Communications. Berlin: Nature, 2023, vol. 14, No 1, p. 1-18. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-023-37988-7.

@article{2383601,
 author = {Sulzen, Hagen and Began, Jakub and Dhillon, Arun and Kereiche, Sami and Pompach, Petr and Votrubova, Jitka and Zahedifard, Farnaz and Subrtova, Adriana and Safner, Marie and Hubalek, Martin and Thompson, Maaike and Zoltner, Martin and Zoll, Sebastian},
 article_location = {Berlin},
 article_number = {1},
 doi = {http://dx.doi.org/10.1038/s41467-023-37988-7},
 keywords = {VARIANT SURFACE GLYCOPROTEIN; ANTIGENIC DETERMINANTS; SPONTANEOUS HYDROLYSIS; HUMAN-SERUM; PROTEIN; resistance},
 language = {eng},
 issn = {2041-1723},
 journal = {Nature Communications},
 title = {Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction},
 url = {https://www.nature.com/articles/s41467-023-37988-7},
 volume = {14},
 year = {2023}
}

TY - JOUR
ID - 2383601
AU - Sulzen, Hagen - Began, Jakub - Dhillon, Arun - Kereiche, Sami - Pompach, Petr - Votrubova, Jitka - Zahedifard, Farnaz - Subrtova, Adriana - Safner, Marie - Hubalek, Martin - Thompson, Maaike - Zoltner, Martin - Zoll, Sebastian
PY - 2023
TI - Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction
JF - Nature Communications
VL - 14
IS - 1
SP - 1-18
EP - 1-18
PB - Nature
SN - 20411723
KW - VARIANT SURFACE GLYCOPROTEIN
KW - ANTIGENIC DETERMINANTS
KW - SPONTANEOUS HYDROLYSIS
KW - HUMAN-SERUM
KW - PROTEIN
KW - resistance
UR - https://www.nature.com/articles/s41467-023-37988-7
N2 - African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement interaction.
ER -

SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER and Sebastian ZOLL. Cryo-EM structures of \&{}lt;i\&{}gt;Trypanosoma brucei gambiense\&{}lt;/i\&{}gt; ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. \textit{Nature Communications}. Berlin: Nature, 2023, vol.~14, No~1, p.~1-18. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-023-37988-7.

Detailed Information on Publication Record

Cryo-EM structures of <i>Trypanosoma brucei gambiense</i> ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction