| SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER and Sebastian ZOLL. Cryo-EM structures of <i>Trypanosoma brucei gambiense</i> ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nature Communications. Berlin: Nature, 2023, vol. 14, No 1, p. 1-18. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-023-37988-7. |
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@article{2383601,
author = {Sulzen, Hagen and Began, Jakub and Dhillon, Arun and Kereiche, Sami and Pompach, Petr and Votrubova, Jitka and Zahedifard, Farnaz and Subrtova, Adriana and Safner, Marie and Hubalek, Martin and Thompson, Maaike and Zoltner, Martin and Zoll, Sebastian},
article_location = {Berlin},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41467-023-37988-7},
keywords = {VARIANT SURFACE GLYCOPROTEIN; ANTIGENIC DETERMINANTS; SPONTANEOUS HYDROLYSIS; HUMAN-SERUM; PROTEIN; resistance},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Cryo-EM structures of <i>Trypanosoma brucei gambiense</i> ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction},
url = {https://www.nature.com/articles/s41467-023-37988-7},
volume = {14},
year = {2023}
}
TY - JOUR
ID - 2383601
AU - Sulzen, Hagen - Began, Jakub - Dhillon, Arun - Kereiche, Sami - Pompach, Petr - Votrubova, Jitka - Zahedifard, Farnaz - Subrtova, Adriana - Safner, Marie - Hubalek, Martin - Thompson, Maaike - Zoltner, Martin - Zoll, Sebastian
PY - 2023
TI - Cryo-EM structures of <i>Trypanosoma brucei gambiense</i> ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction
JF - Nature Communications
VL - 14
IS - 1
SP - 1-18
EP - 1-18
PB - Nature
SN - 20411723
KW - VARIANT SURFACE GLYCOPROTEIN
KW - ANTIGENIC DETERMINANTS
KW - SPONTANEOUS HYDROLYSIS
KW - HUMAN-SERUM
KW - PROTEIN
KW - resistance
UR - https://www.nature.com/articles/s41467-023-37988-7
N2 - African Trypanosomes have developed elaborate immune evasion mechanisms. Here, the authors present the cryoelectron microscopy structures of a trypanosome surface receptor with human complement C3 and C3b, revealing several modes of complement interaction.
ER -
SULZEN, Hagen, Jakub BEGAN, Arun DHILLON, Sami KEREICHE, Petr POMPACH, Jitka VOTRUBOVA, Farnaz ZAHEDIFARD, Adriana SUBRTOVA, Marie SAFNER, Martin HUBALEK, Maaike THOMPSON, Martin ZOLTNER and Sebastian ZOLL. Cryo-EM structures of \&{}lt;i\&{}gt;Trypanosoma brucei gambiense\&{}lt;/i\&{}gt; ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. \textit{Nature Communications}. Berlin: Nature, 2023, vol.~14, No~1, p.~1-18. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-023-37988-7.
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