J 2024

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Marek BARTOŇ, Luboš BRABENEC, Žaneta ŽELEZNÍKOVÁ et. al.

Basic information

Original name

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Authors

NOVÁKOVÁ, Ľubomíra (703 Slovakia, guarantor, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Luboš BRABENEC (203 Czech Republic, belonging to the institution), Žaneta ŽELEZNÍKOVÁ (703 Slovakia, belonging to the institution), Ivona MORÁVKOVÁ (703 Slovakia, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)

Edition

PARKINSONISM & RELATED DISORDERS, London, ELSEVIER SCI LTD, 2024, 1353-8020

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.100 in 2022

Organization unit

Faculty of Medicine

DOI

UT WoS

001188128400001

Keywords in English

striatum; functional connectivity; MCI; Lewy bodies

Tags

Tags

International impact, Reviewed
Změněno: 21/8/2024 10:58, Mgr. Tereza Miškechová

Abstract

V originále

Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender-matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed-based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between-group differences and neuropsychological scores of interest (visuospatial and executive domains z-scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre-dementia stages and enhance research of disease modifying therapy.

Links

LM2018129, research and development project
Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging
Investor: Ministry of Education, Youth and Sports of the CR
LX22NPO5107, research and development project
Name: Národní ústav pro neurologický výzkum
Investor: Ministry of Education, Youth and Sports of the CR, 5.1 EXCELES
NU20-04-00294, research and development project
Name: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat
Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis
90249, large research infrastructures
Name: CZECRIN IV