NOVÁKOVÁ, Ľubomíra, Martin GAJDOŠ, Marek BARTOŇ, Luboš BRABENEC, Žaneta ŽELEZNÍKOVÁ, Ivona MORÁVKOVÁ and Irena REKTOROVÁ. Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies. PARKINSONISM & RELATED DISORDERS. London: ELSEVIER SCI LTD, 2024, vol. 121, April 2024, p. 1-8. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2024.106031.
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Basic information
Original name Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies
Authors NOVÁKOVÁ, Ľubomíra (703 Slovakia, guarantor, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Luboš BRABENEC (203 Czech Republic, belonging to the institution), Žaneta ŽELEZNÍKOVÁ (703 Slovakia, belonging to the institution), Ivona MORÁVKOVÁ (703 Slovakia, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution).
Edition PARKINSONISM & RELATED DISORDERS, London, ELSEVIER SCI LTD, 2024, 1353-8020.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30210 Clinical neurology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.100 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.parkreldis.2024.106031
UT WoS 001188128400001
Keywords in English striatum; functional connectivity; MCI; Lewy bodies
Tags 14110127, podil
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 15/7/2024 12:19.
Abstract
Background: Functional connectivity changes in clinically overt neurodegenerative diseases such as dementia with Lewy bodies have been described, but studies on connectivity changes in the pre-dementia phase are scarce. Objectives: We concentrated on evaluating striato-cortical functional connectivity differences between patients with Mild Cognitive Impairment with Lewy bodies and healthy controls and on assessing the relation to cognition. Methods: Altogether, we enrolled 77 participants (47 patients, of which 35 met all the inclusion criteria for the final analysis, and 30 age- and gender-matched healthy controls, of which 28 met all the inclusion criteria for the final analysis) to study the seed-based connectivity of the dorsal, middle, and ventral striatum. We assessed correlations between functional connectivity in the regions of between-group differences and neuropsychological scores of interest (visuospatial and executive domains z-scores). Results: Subjects with Mild Cognitive Impairment with Lewy Bodies, as compared to healthy controls, showed increased connectivity from the dorsal part of the striatum particularly to the bilateral anterior part of the temporal cortex with an association with executive functions. Conclusions: We were able to capture early abnormal connectivity within cholinergic and noradrenergic pathways that correlated with cognitive functions known to be linked to cholinergic/noradrenergic deficits. The knowledge of specific alterations may improve our understanding of early neural changes in pre-dementia stages and enhance research of disease modifying therapy.
Links
LM2018129, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging
Investor: Ministry of Education, Youth and Sports of the CR
LX22NPO5107, research and development projectName: Národní ústav pro neurologický výzkum
Investor: Ministry of Education, Youth and Sports of the CR, 5.1 EXCELES
NU20-04-00294, research and development projectName: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat
Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis
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