| FARSA, Oldřich, Veronika BALLAYOVÁ, Radka ŽÁČKOVÁ and Peter ZUBÁČ. Aminopeptidase N as a potential drug target. European Pharmaceutical Journal. Sciendo, 2023, vol. 70, s2, p. „AoP,1“-„2“, 2 pp. ISSN 2453-6725. Available from: https://dx.doi.org/10.2478/afpuc-2024-0002. |
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@article{2384277,
author = {Farsa, Oldřich and Ballayová, Veronika and Žáčková, Radka and Zubáč, Peter},
article_number = {s2},
doi = {http://dx.doi.org/10.2478/afpuc-2024-0002},
keywords = {aminopeptidase N; inhibitors; antitumor activity; anti-infectious activity},
language = {eng},
issn = {2453-6725},
journal = {European Pharmaceutical Journal},
title = {Aminopeptidase N as a potential drug target},
url = {https://sciendo.com/issue/AFPUC/0/0},
volume = {70},
year = {2023}
}
TY - JOUR
ID - 2384277
AU - Farsa, Oldřich - Ballayová, Veronika - Žáčková, Radka - Zubáč, Peter
PY - 2023
TI - Aminopeptidase N as a potential drug target
JF - European Pharmaceutical Journal
VL - 70
IS - s2
SP - „AoP,1“-„2“
EP - „AoP,1“-„2“
PB - Sciendo
SN - 24536725
KW - aminopeptidase N
KW - inhibitors
KW - antitumor activity
KW - anti-infectious activity
UR - https://sciendo.com/issue/AFPUC/0/0
N2 - Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of some coronaviruses. Some APN inhibitors, such as bestatin or tosedostat, were used or tested as anticancer drugs in the past. Within the past two decades, we have prepared several series of potential APN inhibitors. Some of them reached interesting values of inhibitory activity and were also successfully tested for antiproliferation activity in cancer cell lines. We also performed some QSAR studies with APN inhibitors prepared by us and other authors.
ER -
FARSA, Oldřich, Veronika BALLAYOVÁ, Radka ŽÁČKOVÁ and Peter ZUBÁČ. Aminopeptidase N as a potential drug target. \textit{European Pharmaceutical Journal}. Sciendo, 2023, vol.~70, s2, p.~„AoP,1“-„2“, 2 pp. ISSN~2453-6725. Available from: https://dx.doi.org/10.2478/afpuc-2024-0002.
|
