NON-INVASIVE PPG-BASED ESTIMATION OF BLOOD GLUCOSE LEVEL

VARGOVÁ, Enikö, Andrea NĚMCOVÁ and Zuzana NOVÁKOVÁ. NON-INVASIVE PPG-BASED ESTIMATION OF BLOOD GLUCOSE LEVEL. Lékař a technika. Praha: Czech Society for Biomedical Engineering and Medical Informatics, 2023, vol. 53, No 1, p. 19-24. ISSN 0301-5491. Available from: https://dx.doi.org/10.14311/CTJ.2023.1.04.

Basic information

• Original name: NON-INVASIVE PPG-BASED ESTIMATION OF BLOOD GLUCOSE LEVEL
• Authors: VARGOVÁ, Enikö (203 Czech Republic), Andrea NĚMCOVÁ and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Lékař a technika, Praha, Czech Society for Biomedical Engineering and Medical Informatics, 2023, 0301-5491.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14110/23:00133826
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.14311/CTJ.2023.1.04
• Keywords in English: non-invasive blood glucose determination; PPG
• Tags: Reviewed

Abstract

This paper focuses on non-invasive blood glucose determination using photoplethysmographic (PPG) signals, which is crucial for managing diabetes. Diabetes stands as one of the world’s major chronic diseases. Untreated diabetes frequently leads to fatalities. Current self-monitoring techniques for measuring diabetes require invasive procedures such as blood or bodily fluid sampling, which may be very uncomfortable. Hence, there is an opportunity for non-invasive blood glucose monitoring through smart devices capable of measuring PPG signals. The primary goal of this research was to propose methods for glycemic classification into two groups (low and high glycemia) and to predict specific glycemia values using machine learning techniques. Two datasets were created by measuring PPG signals from 16 individuals using two different smart devices – a smart wristband and a smartphone. Simultaneously, the reference blood glucose levels were invasively measured using a glucometer. The PPG signals were preprocessed, and 27 different features were extracted. With the use of feature selection, only 10 relevant features were chosen. Numerous machine learning models were developed. Random Forest (RF) and Support Vector Machine (SVM) with the radial basis function (RBF) kernel performed best in classifying PPG signals into two groups. These models achieved an accuracy of 76% (SVM) and 75% (RF) on the smart wristband test dataset. The functionality of the proposed models was then verified on the smartphone test dataset, where both models achieved similar accuracy: 74% (SVM) and 75% (RF). For predicting specific glycemia values, RF performed best. Mean Absolute Error (MAE) was 1.25 mmol/l on the smart wristband test dataset and 1.37 mmol/l on the smartphone test dataset.

Links

• MUNI/A/1343/2022, interní kód MU: Name: Zátěže kardiovaskulárního systému od A po Z

Investor: Masaryk University, Loads on the cardiovascular system from A to Z