MISMATCH-REPAIR DEFICIENCY IS ASSOCIATED WITH A HIGHER RISK OF RECURRENCE THAN NO SPECIFIC MOLECULAR PROFILE IN EARLY-STAGE ENDOMETRIAL CANCER

BEDNAŘÍKOVÁ, Markéta; Jitka HAUSNEROVÁ; Roman HRSTKA; Petra OVESNÁ; Lucie MOUKOVÁ; Petra BRETOVÁ; Alice HLOBILKOVÁ; Michaela KOBLÍŽKOVÁ; Dita MÜNZOVÁ and Vít WEINBERGER. MISMATCH-REPAIR DEFICIENCY IS ASSOCIATED WITH A HIGHER RISK OF RECURRENCE THAN NO SPECIFIC MOLECULAR PROFILE IN EARLY-STAGE ENDOMETRIAL CANCER. In ESGO 2024. 2024. Available from: https://doi.org/10.1136/ijgc-2024-ESGO.413.

Basic information

Original name

MISMATCH-REPAIR DEFICIENCY IS ASSOCIATED WITH A HIGHER RISK OF RECURRENCE THAN NO SPECIFIC MOLECULAR PROFILE IN EARLY-STAGE ENDOMETRIAL CANCER

Authors

BEDNAŘÍKOVÁ, Markéta; Jitka HAUSNEROVÁ; Roman HRSTKA; Petra OVESNÁ; Lucie MOUKOVÁ; Petra BRETOVÁ; Alice HLOBILKOVÁ; Michaela KOBLÍŽKOVÁ; Dita MÜNZOVÁ and Vít WEINBERGER

Edition

ESGO 2024, 2024

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Other information

Language

English

Type of outcome

Conference abstract

Confidentiality degree

is not subject to a state or trade secret

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1136/ijgc-2024-ESGO.413

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Abstract

In the original language

The prognostic significance of MMR deficiency (MMRd) has not been unequivocally established yet. Thus, treatment recommendations for newly diagnosed early MMRd EC patients do not differ from those with no specific molecular profile (NSMP). As a part of our research project concerning EC, this study aimed to assess the prognostic significance of MMR status and to compare clinical outcomes between MMRd and NSMP cohorts (defined as those with MMR-proficient and non-POLE ultra-mutated, TP53-wild type tumors).