GALAZ, Zoltan, Jiri MEKYSKA, Jan MUCHA, Vojtech ZVONCAK, Zdenek SMEKAL, Marcos FAUNDEZ-ZANUY, Luboš BRABENEC, Ivona MORÁVKOVÁ and Irena REKTOROVÁ. Prodromal Diagnosis of Lewy Body Diseases Based on the Assessment of Graphomotor and Handwriting Difficulties. In Cristina Carmona-Duarte, Moises Diaz, Miguel A. Ferrer, Aythami Morales. Intertwining Graphonomics with Human Movements. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG, 2022, p. 255-268. ISBN 978-3-031-19744-4. Available from: https://dx.doi.org/10.1007/978-3-031-19745-1_19.
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Basic information
Original name Prodromal Diagnosis of Lewy Body Diseases Based on the Assessment of Graphomotor and Handwriting Difficulties
Authors GALAZ, Zoltan, Jiri MEKYSKA (203 Czech Republic), Jan MUCHA (203 Czech Republic), Vojtech ZVONCAK (203 Czech Republic), Zdenek SMEKAL (203 Czech Republic), Marcos FAUNDEZ-ZANUY, Luboš BRABENEC (203 Czech Republic, belonging to the institution), Ivona MORÁVKOVÁ (703 Slovakia, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution).
Edition CHAM, Intertwining Graphonomics with Human Movements, p. 255-268, 14 pp. 2022.
Publisher SPRINGER INTERNATIONAL PUBLISHING AG
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30210 Clinical neurology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
WWW Correction version Original version
Impact factor Impact factor: 0.402 in 2005
RIV identification code RIV/00216224:14110/22:00134722
Organization unit Faculty of Medicine
ISBN 978-3-031-19744-4
ISSN 0302-9743
Doi http://dx.doi.org/10.1007/978-3-031-19745-1_19
UT WoS 000913319000019
Keywords in English Lewy body diseases; Online handwriting; Graphomotor difficulties; Handwriting difficulties; Machine learning; Prodromal diagnosis
Tags podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 5/8/2024 08:08.
Abstract
To this date, studies focusing on the prodromal diagnosis of Lewy body diseases (LBDs) based on quantitative analysis of graphomotor and handwriting difficulties are missing. In this work, we enrolled 18 subjects diagnosed with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB), 7 subjects having more than 50% probability of developing Parkinson's disease (PD), 21 subjects with both possible/probable MCI-LB and probability of PD > 50%, and 37 age- and gender-matched healthy controls (HC). Each participant performed three tasks: Archimedean spiral drawing (to quantify graphomotor difficulties), sentence writing task (to quantify handwriting difficulties), and pentagon copying test (to quantify cognitive decline). Next, we parameterized the acquired data by various temporal, kinematic, dynamic, spatial, and task-specific features. And finally, we trained classification models for each task separately as well as a model for their combination to estimate the predictive power of the features for the identification of LBDs. Using this approach we were able to identify prodromal LBDs with 74% accuracy and showed the promising potential of computerized objective and non-invasive diagnosis of LBDs based on the assessment of graphomotor and handwriting difficulties.
Links
NU20-04-00294, research and development projectName: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat
Investor: Ministry of Health of the CR, Diagnostics of Lewy body diseases in prodromal stage based on multimodal data analysis
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