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@article{2386141,
author = {Mikula, Premysl and Hollerova, Aneta and Hodkovicova, Nikola and Doubkova, Veronika and Marsalek, Petr and Franc, Aleš and Sedláčková, Lucie and Hesova, Renata and Modra, Helena and Svobodova, Zdenka and Blahova, Jana},
article_location = {AMSTERDAM},
article_number = {170296},
doi = {http://dx.doi.org/10.1016/j.scitotenv.2024.170296},
keywords = {Fish; Haematological indices; Oxidative stress; Plasma biochemistry; Gene expression; Thyroid disruption},
language = {eng},
issn = {0048-9697},
journal = {Science of the Total Environment},
title = {Long-term dietary exposure to the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen can affect the physiology of common carp (<i>Cyprinus carpio</i>) on multiple levels, even at "environmentally relevant" concentrations},
url = {https://pdf.sciencedirectassets.com/271800/1-s2.0-S0048969723X00539/1-s2.0-S0048969724004315/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEPv%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIB7ygSN7EtJ7OHpVleXD5FBKvVnuo6zRDRE6Z9lnHYHZAiAxYodWZ3WbxKh},
volume = {917},
year = {2024}
}
TY - JOUR
ID - 2386141
AU - Mikula, Premysl - Hollerova, Aneta - Hodkovicova, Nikola - Doubkova, Veronika - Marsalek, Petr - Franc, Aleš - Sedláčková, Lucie - Hesova, Renata - Modra, Helena - Svobodova, Zdenka - Blahova, Jana
PY - 2024
TI - Long-term dietary exposure to the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen can affect the physiology of common carp (<i>Cyprinus carpio</i>) on multiple levels, even at "environmentally relevant" concentrations
JF - Science of the Total Environment
VL - 917
IS - 170296
SP - 1-15
EP - 1-15
PB - Elsevier
SN - 00489697
KW - Fish
KW - Haematological indices
KW - Oxidative stress
KW - Plasma biochemistry
KW - Gene expression
KW - Thyroid disruption
UR - https://pdf.sciencedirectassets.com/271800/1-s2.0-S0048969723X00539/1-s2.0-S0048969724004315/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEPv%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIB7ygSN7EtJ7OHpVleXD5FBKvVnuo6zRDRE6Z9lnHYHZAiAxYodWZ3WbxKh
N2 - The aim of the study was to evaluate the effects of emerging environmental contaminants, the non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac (DCF) and ibuprofen (IBP), on physiological functions in juvenile common carp (Cyprinus carpio). Fish were exposed for 6 weeks, and for the first time, NSAIDs were administered through diet. Either substance was tested at two concentrations, 20 or 2000 mu g/kg, resulting in four different treatments (DCF 20, DCF 2000, IBP 20, IBP 2000). The effects on haematological and biochemical profiles, the biomarkers of oxidative stress, and endocrine disruption were studied, and changes in RNA transcription were also monitored to obtain a comprehensive picture of toxicity. Fish exposure to high concentrations of NSAIDs (DCF 2000, IBP 2000) elicited numerous statistically significant changes (p < 0.05) in the endpoints investigated, with DCF being almost always more efficient than IBP. Compared to control fish, a decrease in total leukocyte count attributed to relative lymphopenia was observed. Plasma concentrations of total proteins, ammonia, and thyroxine, and enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase, and alkaline phosphatase (ALP) were significantly elevated in either group, as were the activities of certain hepatic antioxidant enzymes (superoxide dismutase, glutathione-S-transferase) in the DCF 2000 group. The transcriptomic profile of selected genes in the tissues of exposed fish was affected as well. Significant changes in plasma total proteins, ammonia, ALT, and ALP, as well as in the transcription of genes related to thyroid function and the antioxidant defense of the organism, were found even in fish exposed to the lower DCF concentration (DCF 20). As it was chosen to match DCF concentrations commonly detected in aquatic invertebrates (i.e., the potential feed source of fish), it can be considered "environmentally relevant". Future research is necessary to shed more light on the dietary NSAID toxicity to fish.
ER -
MIKULA, Premysl, Aneta HOLLEROVA, Nikola HODKOVICOVA, Veronika DOUBKOVA, Petr MARSALEK, Aleš FRANC, Lucie SEDLÁČKOVÁ, Renata HESOVA, Helena MODRA, Zdenka SVOBODOVA and Jana BLAHOVA. Long-term dietary exposure to the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen can affect the physiology of common carp (\&{}lt;i\&{}gt;Cyprinus carpio\&{}lt;/i\&{}gt;) on multiple levels, even at ''environmentally relevant'' concentrations. \textit{Science of the Total Environment}. AMSTERDAM: Elsevier, 2024, vol.~917, No~170296, p.~1-15. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2024.170296.
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