POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335
POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

J 2023

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA et. al.

Basic information

Original name

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

Authors

HUBACEK, Jaroslav A (203 Czech Republic), Tom PHILIPP (203 Czech Republic), Vera ADAMKOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Dana DLOUHA (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

Central European journal of public health, Praha, Česká lékařská společnost J.E. Purkyně, 2023, 1210-7778

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.200 in 2022

RIV identification code

RIV/00216224:14110/23:00133875

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.21101/cejph.a7906

UT WoS

001166654700002

Keywords in English

COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335

Abstract

V originále

Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.

Citovat

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA and Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. Central European journal of public health. Praha: Česká lékařská společnost J.E. Purkyně, 2023, vol. 31, No 4, p. 235-239. ISSN 1210-7778. Available from: https://dx.doi.org/10.21101/cejph.a7906.

@article{2386697,
   author = {Hubacek, Jaroslav A and Philipp, Tom and Adamkova, Vera and Májek, Ondřej and Dlouha, Dana and Dušek, Ladislav},
   article_location = {Praha},
   article_number = {4},
   doi = {http://dx.doi.org/10.21101/cejph.a7906},
   keywords = {COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335},
   language = {eng},
   issn = {1210-7778},
   journal = {Central European journal of public health},
   title = {POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION},
   url = {https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php},
   volume = {31},
   year = {2023}
}

TY  - JOUR
ID  - 2386697
AU  - Hubacek, Jaroslav A - Philipp, Tom - Adamkova, Vera - Májek, Ondřej - Dlouha, Dana - Dušek, Ladislav
PY  - 2023
TI  - POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION
JF  - Central European journal of public health
VL  - 31
IS  - 4
SP  - 235-239
EP  - 235-239
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 12107778
KW  - COVID-19
KW  - DPP4
KW  - OAS1
KW  - polymorphism
KW  - SARS-CoV-2
KW  - severity
KW  - TMPRSS6
KW  - ZNF335
UR  - https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php
N2  - Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.
ER  -

HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA and Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. \textit{Central European journal of public health}. Praha: Česká lékařská společnost J.E. Purkyně, 2023, vol.~31, No~4, p.~235-239. ISSN~1210-7778. Available from: https://dx.doi.org/10.21101/cejph.a7906.

Detailed Information on Publication Record