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@article{2386697,
author = {Hubacek, Jaroslav A and Philipp, Tom and Adamkova, Vera and Májek, Ondřej and Dlouha, Dana and Dušek, Ladislav},
article_location = {Praha},
article_number = {4},
doi = {http://dx.doi.org/10.21101/cejph.a7906},
keywords = {COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335},
language = {eng},
issn = {1210-7778},
journal = {Central European journal of public health},
title = {POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION},
url = {https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php},
volume = {31},
year = {2023}
}
TY - JOUR
ID - 2386697
AU - Hubacek, Jaroslav A - Philipp, Tom - Adamkova, Vera - Májek, Ondřej - Dlouha, Dana - Dušek, Ladislav
PY - 2023
TI - POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION
JF - Central European journal of public health
VL - 31
IS - 4
SP - 235-239
EP - 235-239
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107778
KW - COVID-19
KW - DPP4
KW - OAS1
KW - polymorphism
KW - SARS-CoV-2
KW - severity
KW - TMPRSS6
KW - ZNF335
UR - https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php
N2 - Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.
ER -
HUBACEK, Jaroslav A, Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK, Dana DLOUHA and Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. \textit{Central European journal of public health}. Praha: Česká lékařská společnost J.E. Purkyně, 2023, vol.~31, No~4, p.~235-239. ISSN~1210-7778. Available from: https://dx.doi.org/10.21101/cejph.a7906.
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