Structural parameters defining distribution of collagen fiber
directions in human carotid arteries

J 2024

Structural parameters defining distribution of collagen fiber directions in human carotid arteries

FISCHER, Jiří, Aneta HEIDROVÁ, Markéta HERMANOVÁ, Zdeněk BEDNAŘÍK, Marek JOUKAL et. al.

Basic information

Original name

Structural parameters defining distribution of collagen fiber directions in human carotid arteries

Authors

FISCHER, Jiří (203 Czech Republic), Aneta HEIDROVÁ (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Zdeněk BEDNAŘÍK (203 Czech Republic, belonging to the institution), Marek JOUKAL (203 Czech Republic, belonging to the institution) and Jiří BURŠA (203 Czech Republic)

Edition

Journal of the Mechanical Behavior of Biomedical Materials, AMSTERDAM, ELSEVIER, 2024, 1751-6161

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.900 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jmbbm.2024.106494

UT WoS

001219297800001

Keywords in English

Arterial wall; Carotid artery; Collagen fiber direction; Polarized light microscopy; Histogram

Abstract

V originále

Collagen fiber arrangement is decisive for constitutive description of anisotropic mechanical response of arterial wall. In this study, their orientation in human common carotid artery was investigated using polarized light microscopy and an automated algorithm giving more than 4·106 fiber angles per slice. In total 113 slices acquired from 18 arteries taken from 14 cadavers were used for fiber orientation in the circumferential-axial plane. All histograms were approximated with unimodal von Mises distribution to evaluate dominant direction of fibers and their concentration parameter. 10 specimens were analyzed also in circumferential-radial and axial-radial planes (2-4 slices per specimen in each plane); the portion of radially oriented fibers was found insignificant. In the circumferential-axial plane, most specimens showed a pronounced unimodal distribution with angle to circumferential direction μ = 0.7° ± 9.4° and concentration parameter b = 3.4 ± 1.9. Suitability of the unimodal fit was confirmed by high values of coefficient of determination (mean R2 = 0.97, median R2 = 0.99). Differences between media and adventitia layers were not found statistically significant. The results are directly applicable as structural parameters in the GOH constitutive model of arterial wall if the postulated two fiber families are unified into one with circumferential orientation.

Links

GA21-21935S, research and development project

Name: Výpočtové modelování pulzačního proudění v poddajných trubicích s aplikací na tandemovou stenózu karotidy

Investor: Czech Science Foundation

Citovat

FISCHER, Jiří, Aneta HEIDROVÁ, Markéta HERMANOVÁ, Zdeněk BEDNAŘÍK, Marek JOUKAL and Jiří BURŠA. Structural parameters defining distribution of collagen fiber directions in human carotid arteries. Journal of the Mechanical Behavior of Biomedical Materials. AMSTERDAM: ELSEVIER, 2024, vol. 153, May 2024, p. 1-9. ISSN 1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2024.106494.

@article{2387620,
   author = {Fischer, Jiří and Heidrová, Aneta and Hermanová, Markéta and Bednařík, Zdeněk and Joukal, Marek and Burša, Jiří},
   article_location = {AMSTERDAM},
   article_number = {May 2024},
   doi = {http://dx.doi.org/10.1016/j.jmbbm.2024.106494},
   keywords = {Arterial wall; Carotid artery; Collagen fiber direction; Polarized light microscopy; Histogram},
   language = {eng},
   issn = {1751-6161},
   journal = {Journal of the Mechanical Behavior of Biomedical Materials},
   title = {Structural parameters defining distribution of collagen fiber directions in human carotid arteries},
   url = {https://www.sciencedirect.com/science/article/pii/S1751616124001267?via%3Dihub},
   volume = {153},
   year = {2024}
}

TY  - JOUR
ID  - 2387620
AU  - Fischer, Jiří - Heidrová, Aneta - Hermanová, Markéta - Bednařík, Zdeněk - Joukal, Marek - Burša, Jiří
PY  - 2024
TI  - Structural parameters defining distribution of collagen fiber directions in human carotid arteries
JF  - Journal of the Mechanical Behavior of Biomedical Materials
VL  - 153
IS  - May 2024
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER
SN  - 17516161
KW  - Arterial wall
KW  - Carotid artery
KW  - Collagen fiber direction
KW  - Polarized light microscopy
KW  - Histogram
UR  - https://www.sciencedirect.com/science/article/pii/S1751616124001267?via%3Dihub
N2  - Collagen fiber arrangement is decisive for constitutive description of anisotropic mechanical response of arterial wall. In this study, their orientation in human common carotid artery was investigated using polarized light microscopy and an automated algorithm giving more than 4·106 fiber angles per slice. In total 113 slices acquired from 18 arteries taken from 14 cadavers were used for fiber orientation in the circumferential-axial plane. All histograms were approximated with unimodal von Mises distribution to evaluate dominant direction of fibers and their concentration parameter. 10 specimens were analyzed also in circumferential-radial and axial-radial planes (2-4 slices per specimen in each plane); the portion of radially oriented fibers was found insignificant. In the circumferential-axial plane, most specimens showed a pronounced unimodal distribution with angle to circumferential direction μ = 0.7° ± 9.4° and concentration parameter b = 3.4 ± 1.9. Suitability of the unimodal fit was confirmed by high values of coefficient of determination (mean R2 = 0.97, median R2 = 0.99). Differences between media and adventitia layers were not found statistically significant. The results are directly applicable as structural parameters in the GOH constitutive model of arterial wall if the postulated two fiber families are unified into one with circumferential orientation.
ER  -

FISCHER, Jiří, Aneta HEIDROVÁ, Markéta HERMANOVÁ, Zdeněk BEDNAŘÍK, Marek JOUKAL and Jiří BURŠA. Structural parameters defining distribution of collagen fiber directions in human carotid arteries. \textit{Journal of the Mechanical Behavior of Biomedical Materials}. AMSTERDAM: ELSEVIER, 2024, vol.~153, May 2024, p.~1-9. ISSN~1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2024.106494.

Detailed Information on Publication Record