Detailed Information on Publication Record
2023
Changes in dynamic functional connectivity in prodromal dementia with Lewy body
GAJDOŠ, Martin, Marie NOVÁKOVÁ, Pavel ŘÍHA, Irena REKTOROVÁ, Michal MIKL et. al.Basic information
Original name
Changes in dynamic functional connectivity in prodromal dementia with Lewy body
Authors
GAJDOŠ, Martin (203 Czech Republic, guarantor, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution)
Edition
18th European Congress of Clinical Neurophysiology, to be held in Marseille, France, 2023
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30103 Neurosciences
Country of publisher
France
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14740/23:00134725
Organization unit
Central European Institute of Technology
Keywords in English
Dementia with Lewy body; fMRI dynamic functional connectivity; Pearson correlation coefficients
Tags
International impact, Reviewed
Změněno: 11/5/2024 17:06, Mgr. Eva Dubská
Abstract
V originále
Dementia with Lewy body builds significant part of synucleinopathies. Our aim is to study changes in fMRI dynamic functional connectivity characterising the prodromal stage of mild cognitive impairment with Lewy body MCI LB. Sliding window analysis (rectangle windows with length of 61 scans and overlap 90). We computed Pearson correlation coefficients between signals in each window and clustered the correlation matrices with k-means clustering algorithm. 4 states were recommended. We identified the brain state of each time window and evaluated their coverage number of windows spent in the state relative to all windows and density (normalized number of occurrences). Strong feature of state 4 is commonly observed anticorrelation of DMN with most of other resting state networks. Lower normalized number of time spent in state 4 in MCI LB might reflect impairment of prodromal state with respect to healthy controls. Directly proportional relation of state 4 coverage with memory z score in MCI LB group suggests higher damage of memory function in MCI LB participants who spent less time in this state dFC can play role as reasonable parameter for classification of MCI LB patients. Observed results are in concordance with our observations on pilot data.
Links
| LM2015062, research and development project |
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| NU21J-04-00077, research and development project |
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| 90250, large research infrastructures |
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