CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection
in Central European Population

J 2023

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

HUBACEK, Jaroslav A.; Tom PHILIPP; Ondřej MÁJEK; Dana DLOUHA; Vera ADAMKOVA et. al.

Základní údaje

Originální název

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Autoři

HUBACEK, Jaroslav A. (203 Česká republika); Tom PHILIPP (203 Česká republika); Ondřej MÁJEK (203 Česká republika, domácí); Dana DLOUHA (203 Česká republika); Vera ADAMKOVA (203 Česká republika) a Ladislav DUŠEK (203 Česká republika, domácí)

Vydání

Folia biologica, Prague, Charles University, 2023, 0015-5500

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.100

Kód RIV

RIV/00216224:14110/23:00134792

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.14712/fb2023069050181

UT WoS

001199526300002

EID Scopus

2-s2.0-85190398441

Klíčová slova anglicky

COVID-19; CD14; polymorphism; SARS-CoV-2

Štítky

14119612, rivok

Změněno: 29. 4. 2024 13:04, Mgr. Tereza Miškechová

Anotace

V originále

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

Citovat

HUBACEK, Jaroslav A.; Tom PHILIPP; Ondřej MÁJEK; Dana DLOUHA; Vera ADAMKOVA a Ladislav DUŠEK. CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population. Folia biologica. Prague: Charles University, 2023, roč. 69, 5-6, s. 181-185. ISSN 0015-5500. Dostupné z: https://dx.doi.org/10.14712/fb2023069050181.

@article{2398038,
   author = {Hubacek, Jaroslav A. and Philipp, Tom and Májek, Ondřej and Dlouha, Dana and Adamkova, Vera and Dušek, Ladislav},
   article_location = {Prague},
   article_number = {5-6},
   doi = {http://dx.doi.org/10.14712/fb2023069050181},
   keywords = {COVID-19; CD14; polymorphism; SARS-CoV-2},
   language = {eng},
   issn = {0015-5500},
   journal = {Folia biologica},
   title = {CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population},
   url = {https://fb.littledata.cz/69/5/0181/},
   volume = {69},
   year = {2023}
}

TY  - JOUR
ID  - 2398038
AU  - Hubacek, Jaroslav A. - Philipp, Tom - Májek, Ondřej - Dlouha, Dana - Adamkova, Vera - Dušek, Ladislav
PY  - 2023
TI  - CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population
JF  - Folia biologica
VL  - 69
IS  - 5-6
SP  - 181-185
EP  - 181-185
PB  - Charles University
SN  - 00155500
KW  - COVID-19
KW  - CD14
KW  - polymorphism
KW  - SARS-CoV-2
UR  - https://fb.littledata.cz/69/5/0181/
N2  - A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.
ER  -

HUBACEK, Jaroslav A.; Tom PHILIPP; Ondřej MÁJEK; Dana DLOUHA; Vera ADAMKOVA a Ladislav DUŠEK. CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population. \textit{Folia biologica}. Prague: Charles University, 2023, roč.~69, 5-6, s.~181-185. ISSN~0015-5500. Dostupné z: https://dx.doi.org/10.14712/fb2023069050181.

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