CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection
in Central European Population

J 2023

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

HUBACEK, Jaroslav A., Tom PHILIPP, Ondřej MÁJEK, Dana DLOUHA, Vera ADAMKOVA et. al.

Basic information

Original name

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Authors

HUBACEK, Jaroslav A. (203 Czech Republic), Tom PHILIPP (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Dana DLOUHA (203 Czech Republic), Vera ADAMKOVA (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

Folia biologica, Prague, Charles University, 2023, 0015-5500

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.600 in 2022

RIV identification code

RIV/00216224:14110/23:00134792

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14712/fb2023069050181

UT WoS

001199526300002

Keywords in English

COVID-19; CD14; polymorphism; SARS-CoV-2

Abstract

V originále

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

Citovat

HUBACEK, Jaroslav A., Tom PHILIPP, Ondřej MÁJEK, Dana DLOUHA, Vera ADAMKOVA and Ladislav DUŠEK. CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population. Folia biologica. Prague: Charles University, 2023, vol. 69, 5-6, p. 181-185. ISSN 0015-5500. Available from: https://dx.doi.org/10.14712/fb2023069050181.

@article{2398038,
   author = {Hubacek, Jaroslav A. and Philipp, Tom and Májek, Ondřej and Dlouha, Dana and Adamkova, Vera and Dušek, Ladislav},
   article_location = {Prague},
   article_number = {5-6},
   doi = {http://dx.doi.org/10.14712/fb2023069050181},
   keywords = {COVID-19; CD14; polymorphism; SARS-CoV-2},
   language = {eng},
   issn = {0015-5500},
   journal = {Folia biologica},
   title = {CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population},
   url = {https://fb.littledata.cz/69/5/0181/},
   volume = {69},
   year = {2023}
}

TY  - JOUR
ID  - 2398038
AU  - Hubacek, Jaroslav A. - Philipp, Tom - Májek, Ondřej - Dlouha, Dana - Adamkova, Vera - Dušek, Ladislav
PY  - 2023
TI  - CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population
JF  - Folia biologica
VL  - 69
IS  - 5-6
SP  - 181-185
EP  - 181-185
PB  - Charles University
SN  - 00155500
KW  - COVID-19
KW  - CD14
KW  - polymorphism
KW  - SARS-CoV-2
UR  - https://fb.littledata.cz/69/5/0181/
N2  - A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C -> T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case -control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering codominant and recessive genetic models or various between -group comparisons. The CD14 polymor phism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.
ER  -

HUBACEK, Jaroslav A., Tom PHILIPP, Ondřej MÁJEK, Dana DLOUHA, Vera ADAMKOVA and Ladislav DUŠEK. CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population. \textit{Folia biologica}. Prague: Charles University, 2023, vol.~69, 5-6, p.~181-185. ISSN~0015-5500. Available from: https://dx.doi.org/10.14712/fb2023069050181.

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