Coupling between beta band and high frequency oscillations as a
clinically useful biomarker for DBS

J 2024

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

BOČKOVÁ, Martina; Martin LAMOŠ; Jan CHRASTINA; Pavel DANIEL; Silvia KUPCOVÁ et. al.

Basic information

Original name

Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS

Authors

BOČKOVÁ, Martina (203 Czech Republic, belonging to the institution); Martin LAMOŠ (203 Czech Republic, belonging to the institution); Jan CHRASTINA (203 Czech Republic, belonging to the institution); Pavel DANIEL (203 Czech Republic, belonging to the institution); Silvia KUPCOVÁ (703 Slovakia, belonging to the institution); Ivo ŘÍHA (203 Czech Republic, belonging to the institution); Lucia ŠMAHOVSKÁ (703 Slovakia, belonging to the institution); Marek BALÁŽ (703 Slovakia, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

NPJ PARKINSONS DISEASE, BERLIN, NATURE PORTFOLIO, 2024, 2373-8057

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 6.700 in 2023

RIV identification code

RIV/00216224:14110/24:00135902

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41531-024-00656-8

UT WoS

001169223800001

EID Scopus

2-s2.0-85185657521

Keywords in English

DBS

Abstract

In the original language

Beta hypersynchrony was recently introduced into clinical practice in Parkinson's disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication "off" state. Coupling between beta power and HFOs is known to be a correlate of the PD "off" state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

Links

GA21-25953S, research and development project

Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective

90129, large research infrastructures

Name: Czech-BioImaging II

Cite

BOČKOVÁ, Martina; Martin LAMOŠ; Jan CHRASTINA; Pavel DANIEL; Silvia KUPCOVÁ; Ivo ŘÍHA; Lucia ŠMAHOVSKÁ; Marek BALÁŽ and Ivan REKTOR. Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS. NPJ PARKINSONS DISEASE. BERLIN: NATURE PORTFOLIO, 2024, vol. 10, No 1, p. 1-10. ISSN 2373-8057. Available from: https://dx.doi.org/10.1038/s41531-024-00656-8.

@article{2398045,
   author = {Bočková, Martina and Lamoš, Martin and Chrastina, Jan and Daniel, Pavel and Kupcová, Silvia and Říha, Ivo and Šmahovská, Lucia and Baláž, Marek and Rektor, Ivan},
   article_location = {BERLIN},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41531-024-00656-8},
   keywords = {DBS},
   language = {eng},
   issn = {2373-8057},
   journal = {NPJ PARKINSONS DISEASE},
   title = {Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS},
   url = {https://www.nature.com/articles/s41531-024-00656-8},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2398045
AU  - Bočková, Martina - Lamoš, Martin - Chrastina, Jan - Daniel, Pavel - Kupcová, Silvia - Říha, Ivo - Šmahovská, Lucia - Baláž, Marek - Rektor, Ivan
PY  - 2024
TI  - Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS
JF  - NPJ PARKINSONS DISEASE
VL  - 10
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE PORTFOLIO
SN  - 23738057
KW  - DBS
UR  - https://www.nature.com/articles/s41531-024-00656-8
N2  - Beta hypersynchrony was recently introduced into clinical practice in Parkinson's disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication "off" state. Coupling between beta power and HFOs is known to be a correlate of the PD "off" state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.
ER  -

BOČKOVÁ, Martina; Martin LAMOŠ; Jan CHRASTINA; Pavel DANIEL; Silvia KUPCOVÁ; Ivo ŘÍHA; Lucia ŠMAHOVSKÁ; Marek BALÁŽ and Ivan REKTOR. Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS. \textit{NPJ PARKINSONS DISEASE}. BERLIN: NATURE PORTFOLIO, 2024, vol.~10, No~1, p.~1-10. ISSN~2373-8057. Available from: https://dx.doi.org/10.1038/s41531-024-00656-8.

Přehled o publikaci