Influence of metabolic state and body composition on the action
of pharmacological treatment of migraine

J 2024

Influence of metabolic state and body composition on the action of pharmacological treatment of migraine

BRUIJN, Noor, van Lohuizen ROMY, Malgorzata BORON, Mira FITZEK, Francesca GABRIELE et. al.

Basic information

Original name

Influence of metabolic state and body composition on the action of pharmacological treatment of migraine

Authors

BRUIJN, Noor, van Lohuizen ROMY, Malgorzata BORON, Mira FITZEK, Francesca GABRIELE, Giada GIULIANI, Laura MELGAREJO, Pavel ŘEHULKA (203 Czech Republic, belonging to the institution), Gabriele SEBASTIANELLI, Paul TRILLER, Simone VIGNERI, Behiye OZCAN and van den Brink Antoinette MAASSEN

Edition

JOURNAL OF HEADACHE AND PAIN, LONDON, BMC, 2024, 1129-2369

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.400 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s10194-024-01724-3

UT WoS

001160025300001

Keywords in English

CGRP; Metabolic disorders; Diabetes mellitus; Migraine; Obesity; Lifestyle

Abstract

V originále

Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in the fertile years, and in women. Migraine impacts the quality of life of affected individuals tremendously and, in addition, it is associated with highly prevalent metabolic diseases, such as obesity, diabetes mellitus and thyroid dysfunction. Also, the clinical response to drugs might be affected in patients with metabolic disease due to body composition and metabolic change. Therefore, the efficacy of antimigraine drugs could be altered in patients with both migraine and metabolic disease. However, knowledge of the pharmacology and the related clinical effects of antimigraine drugs in patients with metabolic disease are limited. Therefore, and given the clinical relevance, this article provides a comprehensive overview of the current research and hypotheses related to the influence of metabolic state and body composition on the action of antimigraine drugs. In addition, the influence of antimigraine drugs on metabolic functioning and, vice versa, the influence of metabolic diseases and its hormonal modulating medication on migraine activity is outlined. Future exploration on personalizing migraine treatment to individual characteristics is necessary to enhance therapeutic strategies, especially given its increasing significance in recent decades.

Links

LM2023049, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BRUIJN, Noor, van Lohuizen ROMY, Malgorzata BORON, Mira FITZEK, Francesca GABRIELE, Giada GIULIANI, Laura MELGAREJO, Pavel ŘEHULKA, Gabriele SEBASTIANELLI, Paul TRILLER, Simone VIGNERI, Behiye OZCAN and van den Brink Antoinette MAASSEN. Influence of metabolic state and body composition on the action of pharmacological treatment of migraine. JOURNAL OF HEADACHE AND PAIN. LONDON: BMC, 2024, vol. 25, No 1, p. 1-22. ISSN 1129-2369. Available from: https://dx.doi.org/10.1186/s10194-024-01724-3.

@article{2398063,
   author = {Bruijn, Noor and Romy, van Lohuizen and Boron, Malgorzata and Fitzek, Mira and Gabriele, Francesca and Giuliani, Giada and Melgarejo, Laura and Řehulka, Pavel and Sebastianelli, Gabriele and Triller, Paul and Vigneri, Simone and Ozcan, Behiye and Maassen, van den Brink Antoinette},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s10194-024-01724-3},
   keywords = {CGRP; Metabolic disorders; Diabetes mellitus; Migraine; Obesity; Lifestyle},
   language = {eng},
   issn = {1129-2369},
   journal = {JOURNAL OF HEADACHE AND PAIN},
   title = {Influence of metabolic state and body composition on the action of pharmacological treatment of migraine},
   url = {https://www.mdpi.com/2227-9059/12/2/404},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2398063
AU  - Bruijn, Noor - Romy, van Lohuizen - Boron, Malgorzata - Fitzek, Mira - Gabriele, Francesca - Giuliani, Giada - Melgarejo, Laura - Řehulka, Pavel - Sebastianelli, Gabriele - Triller, Paul - Vigneri, Simone - Ozcan, Behiye - Maassen, van den Brink Antoinette
PY  - 2024
TI  - Influence of metabolic state and body composition on the action of pharmacological treatment of migraine
JF  - JOURNAL OF HEADACHE AND PAIN
VL  - 25
IS  - 1
SP  - 1-22
EP  - 1-22
PB  - BMC
SN  - 11292369
KW  - CGRP
KW  - Metabolic disorders
KW  - Diabetes mellitus
KW  - Migraine
KW  - Obesity
KW  - Lifestyle
UR  - https://www.mdpi.com/2227-9059/12/2/404
N2  - Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in the fertile years, and in women. Migraine impacts the quality of life of affected individuals tremendously and, in addition, it is associated with highly prevalent metabolic diseases, such as obesity, diabetes mellitus and thyroid dysfunction. Also, the clinical response to drugs might be affected in patients with metabolic disease due to body composition and metabolic change. Therefore, the efficacy of antimigraine drugs could be altered in patients with both migraine and metabolic disease. However, knowledge of the pharmacology and the related clinical effects of antimigraine drugs in patients with metabolic disease are limited. Therefore, and given the clinical relevance, this article provides a comprehensive overview of the current research and hypotheses related to the influence of metabolic state and body composition on the action of antimigraine drugs. In addition, the influence of antimigraine drugs on metabolic functioning and, vice versa, the influence of metabolic diseases and its hormonal modulating medication on migraine activity is outlined. Future exploration on personalizing migraine treatment to individual characteristics is necessary to enhance therapeutic strategies, especially given its increasing significance in recent decades.
ER  -

BRUIJN, Noor, van Lohuizen ROMY, Malgorzata BORON, Mira FITZEK, Francesca GABRIELE, Giada GIULIANI, Laura MELGAREJO, Pavel ŘEHULKA, Gabriele SEBASTIANELLI, Paul TRILLER, Simone VIGNERI, Behiye OZCAN and van den Brink Antoinette MAASSEN. Influence of metabolic state and body composition on the action of pharmacological treatment of migraine. \textit{JOURNAL OF HEADACHE AND PAIN}. LONDON: BMC, 2024, vol.~25, No~1, p.~1-22. ISSN~1129-2369. Available from: https://dx.doi.org/10.1186/s10194-024-01724-3.

Detailed Information on Publication Record