The Formulation Parameters Effect on the Physicochemical
Properties of Lyophilizates with Probiotics The Formulation
Parameters Effect on the Physicochemical Properties of
Lyophilizates with Probiotics

a 2024

The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics

PAVLOKOVÁ, Sylvie, Nicole FÜLÖPOVÁ, Natália CHOMOVÁ, Aleš FRANC, Dagmar MUDROŇOVÁ et. al.

Basic information

Original name

The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics

Authors

PAVLOKOVÁ, Sylvie, Nicole FÜLÖPOVÁ, Natália CHOMOVÁ, Aleš FRANC, Dagmar MUDROŇOVÁ and Patrik SIVULIČ

Edition

14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2024

Other information

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Keywords (in Czech)

probiotika, lyofilizace, Neusilin, PCA

Keywords in English

probiotics, lyophylization, Neusilin, PCA

Abstract

ORIG CZ

V originále

Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption. Therefore, it is assumed that probiotics protecting animals may also protect the humans who consume them. The composition of the lyophilizate containing the excipient Neusilin® NS2N and the cryoprotectant saccharose was found to be the most suitable in terms of viability, with no significant decrease being observed after a storage period of 6 months, which was chosen as the time limit based on the literature.

In Czech

Probiotika se používají v humánní i veterinární medicíně ke zvýšení odolnosti vůči patogenům a poskytnutí ochrany proti vnějším vlivům po mnoho let. Patogeny jsou často přenášené na člověka konzumací živočišných produktů. Proto se předpokládá, že probiotika chrání zvířata mohou také chránit lidi, kteří je konzumují. Složení lyofilizátu obsahujícího pomocnou látku Neusilin® NS2N a kryoprotektivní sacharózu byl shledán jako nejvhodnější z hlediska životaschopnosti, přičemž nevýznamný pokles byl pozorován po době skladování 6 měsíců, která byla zvolena jako lhůta na základě literatury.

Links

MUNI/IGA/0942/2021, interní kód MU

Name: Formulation of dosage form with probiotics (Lactobacillus) for an oral administration (Acronym: FODPOA)

Investor: Masaryk University

Citovat

PAVLOKOVÁ, Sylvie, Nicole FÜLÖPOVÁ, Natália CHOMOVÁ, Aleš FRANC, Dagmar MUDROŇOVÁ and Patrik SIVULIČ. The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics. In 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 2024.

@proceedings{2398803,
   author = {Pavloková, Sylvie and Fülöpová, Nicole and Chomová, Natália and Franc, Aleš and Mudroňová, Dagmar and Sivulič, Patrik},
   booktitle = {14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology},
   keywords = {probiotics, lyophylization, Neusilin, PCA},
   title = {The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics},
   url = {https://www.worldmeeting.org/home/},
   year = {2024}
}

TY  - CONF
ID  - 2398803
AU  - Pavloková, Sylvie - Fülöpová, Nicole - Chomová, Natália - Franc, Aleš - Mudroňová, Dagmar - Sivulič, Patrik
PY  - 2024
TI  - The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics
KW  - probiotics, lyophylization, Neusilin, PCA
UR  - https://www.worldmeeting.org/home/
N2  - Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption. Therefore, it is assumed that probiotics protecting animals may also protect the humans who consume them. The composition of the lyophilizate containing the excipient Neusilin® NS2N and the cryoprotectant saccharose was found to be the most suitable in terms of viability, with no significant decrease being observed after a storage period of 6 months, which was chosen as the time limit based on the literature.
ER  -

PAVLOKOVÁ, Sylvie, Nicole FÜLÖPOVÁ, Natália CHOMOVÁ, Aleš FRANC, Dagmar MUDROŇOVÁ and Patrik SIVULIČ. The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics The Formulation Parameters Effect on the Physicochemical Properties of Lyophilizates with Probiotics. In \textit{14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology}. 2024.

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