Dynamic functional connectivity in prodromal dementia with Lewy body

GAJDOŠ, Martin, Marie NOVÁKOVÁ, Martin LAMOŠ, Pavel ŘÍHA, Irena REKTOROVÁ and Michal MIKL. Dynamic functional connectivity in prodromal dementia with Lewy body. In Czech – Austrian Workshop on Magnetic Resonance Imaging and Spectroscopy, 2022, Frein an Murz. 2022.

Basic information

• Original name: Dynamic functional connectivity in prodromal dementia with Lewy body
• Authors: GAJDOŠ, Martin, Marie NOVÁKOVÁ, Martin LAMOŠ, Pavel ŘÍHA, Irena REKTOROVÁ and Michal MIKL.
• Edition: Czech – Austrian Workshop on Magnetic Resonance Imaging and Spectroscopy, 2022, Frein an Murz, 2022.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Central European Institute of Technology
• Tags: CF MAFIL
• Tags: International impact, Reviewed

Abstract

In this work, we analyzed dynamic functional connectivity in 56 subjects (25 healthy controls and 31 MCI-LB) in order to detect changes related to early signs of neurodegeneration in the fMRI in brain states related to preparation to the action. We used method called sliding window analysis. We found significant differences in dwell time in one of 4 identified brain states. This dwell time significantly correlated with visuospatial memory in MCI-LB group whereas in HC group was no significant correlation present. Observed changes probably reflect compensatory mechanisms of MCI-LB.

Links

• NU21J-04-00077, research and development project: Name: Využití dynamických parametrů funkční konektivity mozku jako diagnostického biomarkeru neurodegenerativních nemocí

Investor: Ministry of Health of the CR, Biomarkers of neurodegenerative diseases based on dynamic functional connectivity, Subprogram 2 - junior