a 2022

Dynamic functional connectivity in prodromal dementia with Lewy body

GAJDOŠ, Martin, Marie NOVÁKOVÁ, Martin LAMOŠ, Pavel ŘÍHA, Irena REKTOROVÁ et. al.

Basic information

Original name

Dynamic functional connectivity in prodromal dementia with Lewy body

Authors

GAJDOŠ, Martin (203 Czech Republic, guarantor, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Michal MIKL (203 Czech Republic, belonging to the institution)

Edition

Czech – Austrian Workshop on Magnetic Resonance Imaging and Spectroscopy, 2022, Frein an Murz, 2022

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30103 Neurosciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Central European Institute of Technology

Keywords in English

dynamic functional connectivity; neurodegeneration; fMRI; sliding window analysi

Tags

Tags

International impact, Reviewed
Změněno: 22/8/2024 14:27, Mgr. Eva Dubská

Abstract

V originále

In this work, we analyzed dynamic functional connectivity in 56 subjects (25 healthy controls and 31 MCI-LB) in order to detect changes related to early signs of neurodegeneration in the fMRI in brain states related to preparation to the action. We used method called sliding window analysis. We found significant differences in dwell time in one of 4 identified brain states. This dwell time significantly correlated with visuospatial memory in MCI-LB group whereas in HC group was no significant correlation present. Observed changes probably reflect compensatory mechanisms of MCI-LB.

Links

NU21J-04-00077, research and development project
Name: Využití dynamických parametrů funkční konektivity mozku jako diagnostického biomarkeru neurodegenerativních nemocí
Investor: Ministry of Health of the CR, Biomarkers of neurodegenerative diseases based on dynamic functional connectivity, Subprogram 2 - junior