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@article{2401320,
author = {Macejova, Dana and Kollar, Jakub and Bobáľ, Pavel and Otevřel, Jan and Schuster, Daniela and Brtko, Julius},
article_location = {DORDRECHT},
article_number = {Neuvedeno},
doi = {http://dx.doi.org/10.1007/s11010-023-04914-w},
keywords = {Triorganotin isoselenocyanates; Retinoid X receptor; Apoptosis; Breast cancer},
language = {eng},
issn = {0300-8177},
journal = {Molecular and Cellular Biochemistry},
title = {Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer},
url = {https://link.springer.com/content/pdf/10.1007/s11010-023-04914-w.pdf},
volume = {Neuvedeno},
year = {2024}
}
TY - JOUR
ID - 2401320
AU - Macejova, Dana - Kollar, Jakub - Bobáľ, Pavel - Otevřel, Jan - Schuster, Daniela - Brtko, Julius
PY - 2024
TI - Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer
JF - Molecular and Cellular Biochemistry
VL - Neuvedeno
IS - Neuvedeno
SP - 1-16
EP - 1-16
PB - Springer
SN - 03008177
KW - Triorganotin isoselenocyanates
KW - Retinoid X receptor
KW - Apoptosis
KW - Breast cancer
UR - https://link.springer.com/content/pdf/10.1007/s11010-023-04914-w.pdf
N2 - Several commercially available triorganotin compounds were previously found to function as agonist ligands for nuclear retinoid X receptor (RXR) molecules. Triphenyltin isoselenocyanate (TPT-NCSe), a novel selenium atom containing a derivative of triorganotin origin, was found to represent a new cognate bioactive ligand for RXRs. TPT-NCSe displayed a concentration- and time-dependent decrease in the cell viability in both human breast carcinoma MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines. Reactive oxygen species levels generated in response to TPT-NCSe were significantly higher in both carcinoma cell lines treated with TPT-NCSe when compared to mock-treated samples. Treatment with 500 nM TPT-NCSe caused a decrease in SOD1 and increased SOD2 mRNA in MCF-7 cells. The levels of SOD2 mRNA were more increased following the treatment with TPT-NCSe along with 1 mu M all-trans retinoic acid (AtRA) in MCF-7 cells. An increased superoxide dismutase SOD1 and SOD2 mRNA levels were also detected in combination treatment of 500 nM TPT-NCSe and 1 mu M AtRA in TPT-NCSe-treated MDA-MB-231 cells. The data have also shown that TPT-NCSe induces apoptosis via a caspase cascade triggered by the mitochondrial apoptotic pathway. TPT-NCSe modulates the expression levels of apoptosis-related proteins, Annexin A5, Bcl-2 and BAX family proteins, and finally, it enhances the expression levels of its cognate nuclear receptor subtypes RXRalpha and RXRbeta.
ER -
MACEJOVA, Dana, Jakub KOLLAR, Pavel BOBÁĽ, Jan OTEVŘEL, Daniela SCHUSTER and Julius BRTKO. Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer. \textit{Molecular and Cellular Biochemistry}. DORDRECHT: Springer, 2024, Neuvedeno, Neuvedeno, p.~1-16. ISSN~0300-8177. Available from: https://dx.doi.org/10.1007/s11010-023-04914-w.
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