Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility

JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS, Aldona MZYK and Romana SCHIRHAGL. Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T. AMSTERDAM: ELSEVIER, 2024, vol. 30, May-June 2024, p. 283-294. ISSN 2238-7854. Available from: https://dx.doi.org/10.1016/j.jmrt.2024.03.044.

Basic information

• Original name: Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
• Authors: JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS (616 Poland, belonging to the institution), Aldona MZYK and Romana SCHIRHAGL.
• Edition: JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, AMSTERDAM, ELSEVIER, 2024, 2238-7854.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30404 Biomaterials
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 6.400 in 2022
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.jmrt.2024.03.044
• UT WoS: 001224411800001
• Keywords in English: Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys
• Tags: 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.