Detailed Information on Publication Record
2024
Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA et. al.Basic information
Original name
Microstructure-properties relation of hydrostatically extruded absorbable zinc alloys: Effect of Mg and Cu addition on corrosion properties and biocompatibility
Authors
JARZĘBSKA, Anna, Magdalena GIELECIAK, Agnieszka BIGOS, Łukasz MAJ, Klaudia TREMBECKA-WOJCIGA, Monika BUGAJSKA, Magdalena BIEDA, Łukasz ROGAL, Jakub KAWAŁKO, Sylwia PRZYBYSZ, Daniel WOJTAS (616 Poland, belonging to the institution), Aldona MZYK and Romana SCHIRHAGL
Edition
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, AMSTERDAM, ELSEVIER, 2024, 2238-7854
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30404 Biomaterials
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 6.400 in 2022
Organization unit
Faculty of Medicine
UT WoS
001224411800001
Keywords in English
Absorbable zinc alloys; Hydrostatic extrusion; Corrosion behavior; Cytotoxicity of zinc alloys
Tags
International impact, Reviewed
Změněno: 4/6/2024 09:36, Mgr. Tereza Miškechová
Abstract
V originále
Pure Zn is well-known for its appropriate corrosion rate, making it suitable for use as future absorbable implants. Yet, it suffers from insufficient strength, thus, both plastic deformation and alloying are required. Hydrostatic extrusion has proven to be an efficient technique, providing high mechanical properties for zinc alloys. However, its effect on degradation rate and biocompatibility of Zn alloys remains unknown. Thus, within the present study, an attempt to evaluate those properties has been made on hydrostatically extruded pure Zn, Zn–Mg and Zn–Mg–Cu alloys. The materials were characterized by advanced microscopy techniques and uniaxial tensile tests. Corrosion properties were assessed based on electrochemical and static immersion tests. Finally, the cytotoxic effect of zinc extracts on endothelial cells were examined by standard MTT assays combined with confocal imaging. The results showed that hydrostatic extrusion results in significant refinement of α-Zn grains and the intermetallic phase Mg2Zn11 for the investigated alloys. The alloys exhibited ultimate tensile strength exceeding 300 MPa and elongation higher than 20%. Corrosion tests demonstrated that all the materials showed a similar level of degradation rate. Moreover, the uniform distribution of the intermetallic phase contributed to homogeneous corrosion of Zn alloys. Biological studies indicated that the least cytotoxic response in endothelial cells was obtained for the Zn–Mg alloy. Such an effect was caused by the limited amount of released Zn ions in the favor of Mg ions. The refinement of α-Zn grains and intermetallic phases caused by hydrostatic extrusion were key factors determining the performance of Zn-based materials.