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@article{2403757,
author = {Sedláková, Veronika and Mourcos, Sophia and Pupkaitė, Justina and Lunn, Yvonne and Visintini, Sarah and GuzmanandSoto, Irene and Ruel, Marc and Suuronen, Erik and Alarcon, Emilio I},
article_location = {London},
article_number = {May 2024},
doi = {http://dx.doi.org/10.1016/j.actbio.2024.04.008},
keywords = {Heart disease; Clinical trial; Scoping review; Multi-database searching},
language = {eng},
issn = {1742-7061},
journal = {ACTA BIOMATERIALIA},
title = {Biomaterials for direct cardiac repair-A rapid scoping review 2012-2022},
url = {https://www.sciencedirect.com/science/article/pii/S1742706124001818},
volume = {180},
year = {2024}
}
TY - JOUR
ID - 2403757
AU - Sedláková, Veronika - Mourcos, Sophia - Pupkaitė, Justina - Lunn, Yvonne - Visintini, Sarah - Guzman-Soto, Irene - Ruel, Marc - Suuronen, Erik - Alarcon, Emilio I
PY - 2024
TI - Biomaterials for direct cardiac repair-A rapid scoping review 2012-2022
JF - ACTA BIOMATERIALIA
VL - 180
IS - May 2024
SP - 61-81
EP - 61-81
PB - ELSEVIER SCI LTD
SN - 17427061
KW - Heart disease
KW - Clinical trial
KW - Scoping review
KW - Multi-database searching
UR - https://www.sciencedirect.com/science/article/pii/S1742706124001818
N2 - A plethora of biomaterials for heart repair are being tested worldwide for potential clinical application. These therapeutics aim to enhance the quality of life of patients with heart disease using various methods to improve cardiac function. Despite the myriad of therapeutics tested, only a minority of these studied biomaterials have entered clinical trials. This rapid scoping review aims to analyze literature available from 2012 to 2022 with a focus on clinical trials using biomaterials for direct cardiac repair, i.e., where the intended function of the biomaterial is to enhance the repair of the endocardium, myocardium, epicardium or pericardium. This review included neither biomaterials related to stents and valve repair nor biomaterials serving as vehicles for the delivery of drugs. Surprisingly, the literature search revealed that only 8 different biomaterials mentioned in 23 different studies out of 7038 documents (journal articles, conference abstracts or clinical trial entries) have been tested in clinical trials since 2012. All of these, intended to treat various forms of ischaemic heart disease (heart failure, myocardial infarction), were of natural origin and most used direct injections as their delivery method. This review thus reveals notable gaps between groups of biomaterials tested pre-clinically and clinically.
ER -
SEDLÁKOVÁ, Veronika, Sophia MOURCOS, Justina PUPKAITĖ, Yvonne LUNN, Sarah VISINTINI, Irene GUZMAN-SOTO, Marc RUEL, Erik SUURONEN and Emilio I ALARCON. Biomaterials for direct cardiac repair-A rapid scoping review 2012-2022. \textit{ACTA BIOMATERIALIA}. London: ELSEVIER SCI LTD, 2024, vol.~180, May 2024, p.~61-81. ISSN~1742-7061. Available from: https://dx.doi.org/10.1016/j.actbio.2024.04.008.
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