Pulsed laser ablation synthesis of fresh Te nanoparticles for
matrix assisted laser desorption/ionization mass spectrometry
(MALDI-MS) applications

J 2024

Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications

NOVOTNÝ, Karel, Ivo KREMPL, Lukáš PEČINKA, Lukáš MORÁŇ, Petr VAŇHARA et. al.

Basic information

Original name

Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications

Authors

NOVOTNÝ, Karel (203 Czech Republic, belonging to the institution), Ivo KREMPL (203 Czech Republic, belonging to the institution), Lukáš PEČINKA (203 Czech Republic, belonging to the institution), Lukáš MORÁŇ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution) and Josef HAVEL (203 Czech Republic, belonging to the institution)

Edition

Talanta, AMSTERDAM, Elsevier, 2024, 0039-9140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10406 Analytical chemistry

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.100 in 2022

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.talanta.2024.126061

UT WoS

001224430900001

Keywords in English

Pulsed laser ablation synthesis; PLA; MALDI-MS; Tellurium nanoparticles; Te NPs

Abstract

V originále

This work aims to demonstrate the potential of pulsed laser ablation synthesis (PLA) of tellurium nanoparticles (Te NPs) for use in matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications. An experimental laboratory setup for PLA synthesis of fresh Te NPs was designed to prevent unwanted aggregation of uncoated Te NPs and avoid the need to use additional modifiers. Performing pulsed laser ablation synthesis in liquid (PLAL) using acetone was found to be the optimal way of preparing Te NPs. Another possibility is to use commercially available laser ablation devices for laser ablation - inductively coupled plasma mass spectrometry (LA-ICP-MS) to perform PLA in a helium atmosphere, but this approach is less efficient and results in the formation of unwanted larger particles. The prepared Te NPs were studied using the transmission electron microscopy (TEM) and dynamic light scattering (DLS) methods. TEM images showed the formation of Te NP nanochains composed of many crystallized Te NPs with sizes ranging from 8 to 15 nm. The various size distributions of the synthesized Te NPs identified using the DLS method correspond to the size distributions of aggregations rather than individual Te NPs. The synthesized Te NPs were used for a pilot study of their possible use with the MALDI-MS technique. An important effect was observed when Te NPs were used to perform a MALDI-MS analysis of the alpha-cyclodextrin ( alpha-CD) and cucurbit[7]uril (CB7) macrocycles, which consisted in a decline in the formation of matrix adducts. Furthermore, several changes in MALDI-MS mass spectra of intact cells and a positive effect of Te NPs on the crystallization of the MALDI-MS matrix were observed.

Links

GA22-07635S, research and development project

Name: Pokročilé metody přípravy telluridů polokovů a nepřechodných kovů

Investor: Czech Science Foundation

MUNI/A/1301/2022, interní kód MU

Name: Zdroje pro tkáňové inženýrství 13

Investor: Masaryk University

NU23-08-00241, research and development project

Name: Vývoj ex-vivo buněčných modelů pro adenokarcinom pankreatu: markery a cíle pro precizní medicínu

Investor: Ministry of Health of the CR, Development of ex vivo cellular models for pancreatic adenocarcinoma: markers and targets for precision medicine, Subprogram 1 - standard

Citovat

NOVOTNÝ, Karel, Ivo KREMPL, Lukáš PEČINKA, Lukáš MORÁŇ, Petr VAŇHARA and Josef HAVEL. Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications. Talanta. AMSTERDAM: Elsevier, 2024, vol. 274, JUL, p. 126061-126069. ISSN 0039-9140. Available from: https://dx.doi.org/10.1016/j.talanta.2024.126061.

@article{2404959,
   author = {Novotný, Karel and Krempl, Ivo and Pečinka, Lukáš and Moráň, Lukáš and Vaňhara, Petr and Havel, Josef},
   article_location = {AMSTERDAM},
   article_number = {JUL},
   doi = {http://dx.doi.org/10.1016/j.talanta.2024.126061},
   keywords = {Pulsed laser ablation synthesis; PLA; MALDI-MS; Tellurium nanoparticles; Te NPs},
   language = {eng},
   issn = {0039-9140},
   journal = {Talanta},
   title = {Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications},
   url = {https://www.sciencedirect.com/science/article/pii/S0039914024004405?via%3Dihub},
   volume = {274},
   year = {2024}
}

TY  - JOUR
ID  - 2404959
AU  - Novotný, Karel - Krempl, Ivo - Pečinka, Lukáš - Moráň, Lukáš - Vaňhara, Petr - Havel, Josef
PY  - 2024
TI  - Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications
JF  - Talanta
VL  - 274
IS  - JUL
SP  - 126061
EP  - 126061
PB  - Elsevier
SN  - 00399140
KW  - Pulsed laser ablation synthesis
KW  - PLA
KW  - MALDI-MS
KW  - Tellurium nanoparticles
KW  - Te NPs
UR  - https://www.sciencedirect.com/science/article/pii/S0039914024004405?via%3Dihub
N2  - This work aims to demonstrate the potential of pulsed laser ablation synthesis (PLA) of tellurium nanoparticles (Te NPs) for use in matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications. An experimental laboratory setup for PLA synthesis of fresh Te NPs was designed to prevent unwanted aggregation of uncoated Te NPs and avoid the need to use additional modifiers. Performing pulsed laser ablation synthesis in liquid (PLAL) using acetone was found to be the optimal way of preparing Te NPs. Another possibility is to use commercially available laser ablation devices for laser ablation - inductively coupled plasma mass spectrometry (LA-ICP-MS) to perform PLA in a helium atmosphere, but this approach is less efficient and results in the formation of unwanted larger particles. The prepared Te NPs were studied using the transmission electron microscopy (TEM) and dynamic light scattering (DLS) methods. TEM images showed the formation of Te NP nanochains composed of many crystallized Te NPs with sizes ranging from 8 to 15 nm. The various size distributions of the synthesized Te NPs identified using the DLS method correspond to the size distributions of aggregations rather than individual Te NPs. The synthesized Te NPs were used for a pilot study of their possible use with the MALDI-MS technique. An important effect was observed when Te NPs were used to perform a MALDI-MS analysis of the alpha-cyclodextrin ( alpha-CD) and cucurbit[7]uril (CB7) macrocycles, which consisted in a decline in the formation of matrix adducts. Furthermore, several changes in MALDI-MS mass spectra of intact cells and a positive effect of Te NPs on the crystallization of the MALDI-MS matrix were observed.
ER  -

NOVOTNÝ, Karel, Ivo KREMPL, Lukáš PEČINKA, Lukáš MORÁŇ, Petr VAŇHARA and Josef HAVEL. Pulsed laser ablation synthesis of fresh Te nanoparticles for matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) applications. \textit{Talanta}. AMSTERDAM: Elsevier, 2024, vol.~274, JUL, p.~126061-126069. ISSN~0039-9140. Available from: https://dx.doi.org/10.1016/j.talanta.2024.126061.

Detailed Information on Publication Record