Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model

HORSKÁ, Kateřina, Jan KUČERA, Eva DRAŽANOVÁ, Gabriela KUZMÍNOVÁ, Petra AMCHOVÁ, Mária HRICKOVÁ, Jana RUDÁ and Silje SKREDE. Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model. Biomedicine and Pharmacotherapy. ISSY-LES-MOULINEAUX: Elsevier, 2024, vol. 176, July 2024, p. 1-11. ISSN 0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2024.116763.

Basic information

• Original name: Potent synergistic effects of dulaglutide and food restriction in prevention of olanzapine-induced metabolic adverse effects in a rodent model
• Name in Czech: Silné synergické účinky dulaglutidu a omezení příjmu potravy v prevenci metabolických nežádoucích účinků vyvolaných olanzapinem u potkana
• Authors: HORSKÁ, Kateřina (203 Czech Republic, belonging to the institution), Jan KUČERA (203 Czech Republic, belonging to the institution), Eva DRAŽANOVÁ (203 Czech Republic, belonging to the institution), Gabriela KUZMÍNOVÁ (203 Czech Republic), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Mária HRICKOVÁ (703 Slovakia, belonging to the institution), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution) and Silje SKREDE (578 Norway).
• Edition: Biomedicine and Pharmacotherapy, ISSY-LES-MOULINEAUX, Elsevier, 2024, 0753-3322.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: France
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 7.500 in 2022
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.biopha.2024.116763
• UT WoS: 001247722500001
• Keywords in English: Antipsychotic; Olanzapine; metabolic adverse effects; GLP-1 receptor agonist; Schizophrenia
• Tags: 14110516
• Tags: International impact, Reviewed

Abstract

A combined strategy of dulaglutide and food restriction manifested a massive synergistic benefit. GLP-1RAs represent a promising strategy and deserve thorough future research. Our findings underline the potential importance of lifestyle intervention in addition to GLP-1 RA treatment.

Links

• EHP-BFNU-OVNKM-3-048-2020, interní kód MU: Name: Pharmacological reversal of metabolic derrangements induced by antipsychotic treatment in animal models

Investor: Ministry of Finance of the CR, Bilateral Fund

• EHP-BFNU-OVNKM-4-078-2022, interní kód MU: Name: Pharmacological reversal of metabolic derangements induced by antipsychotic treatment in animal models: intensification of the collaboration

Investor: Ministry of Finance of the CR, Bilateral Fund

• LM2018129, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

• LM2023050, research and development project: Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR, Czech BioImaging: National research infrastructure for biological and medical imaging

• MUNI/A/1372/2020, interní kód MU: Name: Preklinický vývoj terapeutických přístupů k redukci nežádoucích metabolických účinků atypických antipsychotik

Investor: Masaryk University

• MUNI/A/1580/2023, interní kód MU: Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti biotrasformace léčiv, behaviorální neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology