Prenatal MAM exposure raises kynurenic acid levels in the
prefrontal cortex of adult rats

J 2024

Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

FRESCURA, Francesca, Tibor ŠTARK, Edoardo TIZIANI, Serena DI MARTINO, Jana RUDÁ et. al.

Basic information

Original name

Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

Name in Czech

Prenatální expozice MAM zvyšuje hladinu kyseliny kynurenové v prefrontální kůře dospělých potkanů

Authors

FRESCURA, Francesca (380 Italy), Tibor ŠTARK (703 Slovakia), Edoardo TIZIANI (380 Italy), Serena DI MARTINO (380 Italy), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution), Filippo DRAGO (380 Italy), Luca FERRARO (380 Italy), Vincenzo MICALE (380 Italy) and Sarah BEGGIATO (380 Italy)

Edition

PHARMACOLOGICAL REPORTS, HEIDELBERG, SPRINGER HEIDELBERG, 2024, 1734-1140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.400 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s43440-024-00604-6

UT WoS

001236296000001

Keywords in English

AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia

Abstract

V originále

The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.

Links

MUNI/A/1580/2023, interní kód MU

Name: Preklinický a klinický výzkum Farmakologického ústavu v oblasti biotrasformace léčiv, behaviorální neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology

Citovat

FRESCURA, Francesca, Tibor ŠTARK, Edoardo TIZIANI, Serena DI MARTINO, Jana RUDÁ, Filippo DRAGO, Luca FERRARO, Vincenzo MICALE and Sarah BEGGIATO. Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats. PHARMACOLOGICAL REPORTS. HEIDELBERG: SPRINGER HEIDELBERG, 2024, vol. 76, No 4, p. 887-894. ISSN 1734-1140. Available from: https://dx.doi.org/10.1007/s43440-024-00604-6.

@article{2405398,
   author = {Frescura, Francesca and Štark, Tibor and Tiziani, Edoardo and Di Martino, Serena and Rudá, Jana and Drago, Filippo and Ferraro, Luca and Micale, Vincenzo and Beggiato, Sarah},
   article_location = {HEIDELBERG},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s43440-024-00604-6},
   keywords = {AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia},
   language = {eng},
   issn = {1734-1140},
   journal = {PHARMACOLOGICAL REPORTS},
   title = {Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats},
   url = {https://link.springer.com/article/10.1007/s43440-024-00604-6},
   volume = {76},
   year = {2024}
}

TY  - JOUR
ID  - 2405398
AU  - Frescura, Francesca - Štark, Tibor - Tiziani, Edoardo - Di Martino, Serena - Rudá, Jana - Drago, Filippo - Ferraro, Luca - Micale, Vincenzo - Beggiato, Sarah
PY  - 2024
TI  - Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats
JF  - PHARMACOLOGICAL REPORTS
VL  - 76
IS  - 4
SP  - 887-894
EP  - 887-894
PB  - SPRINGER HEIDELBERG
SN  - 17341140
KW  - AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia
UR  - https://link.springer.com/article/10.1007/s43440-024-00604-6
N2  - The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.
ER  -

FRESCURA, Francesca, Tibor ŠTARK, Edoardo TIZIANI, Serena DI MARTINO, Jana RUDÁ, Filippo DRAGO, Luca FERRARO, Vincenzo MICALE and Sarah BEGGIATO. Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats. \textit{PHARMACOLOGICAL REPORTS}. HEIDELBERG: SPRINGER HEIDELBERG, 2024, vol.~76, No~4, p.~887-894. ISSN~1734-1140. Available from: https://dx.doi.org/10.1007/s43440-024-00604-6.

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