FRESCURA, Francesca, Tibor ŠTARK, Edoardo TIZIANI, Serena DI MARTINO, Jana RUDÁ, Filippo DRAGO, Luca FERRARO, Vincenzo MICALE and Sarah BEGGIATO. Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats. PHARMACOLOGICAL REPORTS. HEIDELBERG: SPRINGER HEIDELBERG, 2024, p. 1-9. ISSN 1734-1140. Available from: https://dx.doi.org/10.1007/s43440-024-00604-6.
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Basic information
Original name Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats
Name in Czech Prenatální expozice MAM zvyšuje hladinu kyseliny kynurenové v prefrontální kůře dospělých potkanů
Authors FRESCURA, Francesca, Tibor ŠTARK, Edoardo TIZIANI, Serena DI MARTINO, Jana RUDÁ, Filippo DRAGO, Luca FERRARO, Vincenzo MICALE and Sarah BEGGIATO.
Edition PHARMACOLOGICAL REPORTS, HEIDELBERG, SPRINGER HEIDELBERG, 2024, 1734-1140.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.400 in 2022
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s43440-024-00604-6
UT WoS 001236296000001
Keywords in English AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia
Tags 14110516
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 10/6/2024 13:44.
Abstract
The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.
Links
MUNI/A/1580/2023, interní kód MUName: Preklinický a klinický výzkum Farmakologického ústavu v oblasti biotrasformace léčiv, behaviorální neuropsychofarmakologie a personalizované farmakoterapie v onkologii
Investor: Masaryk University, Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology
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