Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells

GÁBOROVÁ, Mária, Mate VAGVOLGYI, Bizhar Ahmed TAYEB, Renata MINORICS, Istvan ZUPKO, Ondřej JURČEK, Szabolcs BENI, Renata KUBÍNOVÁ, Gyorgy Tibor BALOGH and Attila HUNYADI. Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells. ACS Omega. WASHINGTON: American Chemical Society, 2024, vol. 9, No 16, p. 18495-18504. ISSN 2470-1343. Available from: https://dx.doi.org/10.1021/acsomega.4c00800.

Basic information

• Original name: Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells
• Authors: GÁBOROVÁ, Mária (703 Slovakia, belonging to the institution), Mate VAGVOLGYI (348 Hungary), Bizhar Ahmed TAYEB (348 Hungary), Renata MINORICS (348 Hungary), Istvan ZUPKO (348 Hungary), Ondřej JURČEK (203 Czech Republic, belonging to the institution), Szabolcs BENI (348 Hungary), Renata KUBÍNOVÁ (203 Czech Republic, guarantor, belonging to the institution), Gyorgy Tibor BALOGH (348 Hungary) and Attila HUNYADI (348 Hungary).
• Edition: ACS Omega, WASHINGTON, American Chemical Society, 2024, 2470-1343.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10400 1.4 Chemical sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.100 in 2022
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.1021/acsomega.4c00800
• UT WoS: 001200673800001
• Keywords (in Czech): Coleus; diterpeny; glioblastom; NMR; Plectranthus
• Keywords in English: Coleus; diterpene; glioblastoma; NMR; Plectranthus
• Tags: rivok, ÚPL
• Tags: International impact, Reviewed

Abstract

Fourteen diterpenes were isolated from methanol extracts of the aerial parts of Coleus comosus,Coleus forsteri "Marginatus", and Plectranthus ciliatus. The compounds belong to the abietane (1-4, 9-11, and 13), ent-clerodane (5-8), and ent-kaurane (14, 15) classes. Three new compounds were isolated from C. comosus, including 3-O-acetylornatin G (2), 3,12-di-O-acetylornatin G (3), ornatin B methyl ester (5), and ornatin F (4), for which we proposed a revised structure. The structures of the compounds were determined by comprehensive spectroscopic data analysis. The isolated diterpenes were examined in silico for their physicochemical and early ADME properties. Their antiproliferative effects were determined in vitro using human breast (MDA-MB-231 and MCF-7), cervical (HeLa), and glioblastoma (U-87 MG) cancer cell lines. The royleanone- and hydroquinone-type abietane diterpenes (9-13)exhibited the most potent antiproliferative activity against all cancer cell lines tested, particularly against glioblastoma cells, with IC50 values ranging from 1.1 to 15.6 mu M.

Links

• EF18_046/0015974, research and development project: Name: Modernizace České infrastruktury pro integrativní strukturní biologii
• GA23-04655S, research and development project: Name: Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Investor: Czech Science Foundation, Role of prenylation and glycosylation patterns in anti-inflammatory activity and metabolism of natural phenolic compounds

• LM2023042, research and development project: Name: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministry of Education, Youth and Sports of the CR, CIISB - Czech Infrastructure for Integrative Structural Biology