Dibenzocyclooctadiene Lignans from Schisandra chinensis with
Anti-Inflammatory Effects

J 2024

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

RYBNIKÁŘ, Michal; Milan MALANÍK; Karel ŠMEJKAL; Emil ŠVAJDLENKA; Polina SHPET et. al.

Základní údaje

Originální název

Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

Autoři

RYBNIKÁŘ, Michal (203 Česká republika, domácí); Milan MALANÍK (203 Česká republika, domácí); Karel ŠMEJKAL (203 Česká republika, domácí); Emil ŠVAJDLENKA (203 Česká republika, domácí); Polina SHPET (203 Česká republika, domácí); Pavel BABICA (203 Česká republika, domácí); Stefano DALL´ACQUA (380 Itálie); Ondřej SMIŠTÍK (203 Česká republika, domácí); Ondřej JURČEK (203 Česká republika, domácí) a Jakub TREML (203 Česká republika, domácí)

Vydání

International Journal of Molecular Sciences, BASEL, MDPI, 2024, 1661-6596

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.900 v roce 2023

Kód RIV

RIV/00216224:14160/24:00136084

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ijms25063465

UT WoS

001193322800001

EID Scopus

2-s2.0-85189099535

Klíčová slova anglicky

anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis

Štítky

ÚMF, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 2. 2025 09:22, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.

Návaznosti

GA23-04655S, projekt VaV

Název: Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

Investor: Grantová agentura ČR, Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Citovat

RYBNIKÁŘ, Michal; Milan MALANÍK; Karel ŠMEJKAL; Emil ŠVAJDLENKA; Polina SHPET; Pavel BABICA; Stefano DALL´ACQUA; Ondřej SMIŠTÍK; Ondřej JURČEK a Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International Journal of Molecular Sciences. BASEL: MDPI, 2024, roč. 25, č. 6, s. 1-16. ISSN 1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25063465.

@article{2405904,
   author = {Rybnikář, Michal and Malaník, Milan and Šmejkal, Karel and Švajdlenka, Emil and Shpet, Polina and Babica, Pavel and Dall´Acqua, Stefano and Smištík, Ondřej and Jurček, Ondřej and Treml, Jakub},
   article_location = {BASEL},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/ijms25063465},
   keywords = {anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis},
   language = {eng},
   issn = {1661-6596},
   journal = {International Journal of Molecular Sciences},
   title = {Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects},
   url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2405904
AU  - Rybnikář, Michal - Malaník, Milan - Šmejkal, Karel - Švajdlenka, Emil - Shpet, Polina - Babica, Pavel - Dall´Acqua, Stefano - Smištík, Ondřej - Jurček, Ondřej - Treml, Jakub
PY  - 2024
TI  - Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
JF  - International Journal of Molecular Sciences
VL  - 25
IS  - 6
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 16616596
KW  - anti-inflammatory
KW  - antioxidant
KW  - dibenzocyclooctadiene
KW  - gap junction
KW  - lignan
KW  - Schisandra chinensis
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects
N2  - Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.
ER  -

RYBNIKÁŘ, Michal; Milan MALANÍK; Karel ŠMEJKAL; Emil ŠVAJDLENKA; Polina SHPET; Pavel BABICA; Stefano DALL´ACQUA; Ondřej SMIŠTÍK; Ondřej JURČEK a Jakub TREML. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. \textit{International Journal of Molecular Sciences}. BASEL: MDPI, 2024, roč.~25, č.~6, s.~1-16. ISSN~1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms25063465.

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